Objectives
The toe‐brachial index (TBI) is an alternative to the ankle‐brachial index (ABI) in screening for peripheral arterial disease (PAD); however, there is limited evidence comparing their diagnostic accuracy. This study compared the diagnostic accuracy of the ABI and TBI in a population at risk of PAD.
Methods
The sensitivity and specificity of the ABI and TBI were determined by color duplex sonography. Receiver operating characteristic (ROC) analysis was performed.
Results
A total of 119 participants were recruited (75 male and 44 female). The sensitivity for PAD was highest for the TBI (71%; ABI, 45%), and the specificity was highest for the ABI (93%; TBI, 78%). Receiver operating characteristic analysis indicated that the TBI (ROC area, 0.77; P = .0001) had greater clinical efficacy for diagnosis of PAD than the ABI (ROC area, 0.65; P = .005).
Conclusions
In specific populations, the TBI may have greater clinical efficacy than the ABI for diagnosis of PAD.
The activity of UDP-galactose:ceramide galactosyl transferase (CGalT) has been studied in isolated oligodendroglia from bovine brain white matter and myelinating rat brain. The specific activity and activity per mg DNA are 4- and 10-fold higher in rat oligodendroglia compared with neuronal perikarya from rat brain, and is higher in oligodendroglia from myelinating rat brain compared with bovine oligodendroglia. In membranes isolated from oligodendroglia, the specific activity decreased in the order endoplasmic reticulum greater than plasma membrane greater than myelin.
per l(P cells) Unweaned controls 0.39 f 0.08 2.0 f 0.6 9 f 1 Weaned 2 days 0.79 f 0.027 8.8 4.1 50 f 9f W e~e d 2 days + prolactin 0.84 f 0.12* 9.6 f 2.4f 61 f 14f Unweaned + bromocriptine 0.75 f0.10* 9.0 f 2.9. 38 f 7f Unweaned + bromocriptine +progesterone 0.99 f 0.12f 9.1 f 2.lf 33 f 8f Unweaned + bromocriptine + prolactin 0.53 f 0.04 2.9 f 1.2 13f 1
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