Background: Obesity, inflammation and alterations in matrix metalloproteinase-9 (MMP-9) and nitric oxide (NO) levels are involved in the development of polycystic ovary syndrome (PCOS).
Objective: To investigate the relationship of MMP-9, NO and interleukin-10 (IL-10) with the increase in body mass index (BMI) in women with PCOS.
Materials and Methods: Sixty two infertile PCOS women were included in the study. Serum levels of NO, IL-10 and MMP-9 were assessed in the women with increase in BMI.
Results: MMP-9 was significantly increased (p = 0.029) and IL-10 (p = 0.015) was significantly reduced in obese PCOS subjects compared to those with lesser BMI. MMP- 9 levels positively correlated with the duration of infertility (r = 0.253, p = 0.047) and negatively correlated with NO levels (r = - 0.259, p = 0.042). A significant negative correlation between the interleukin-10 levels and the BMI (r = - 0.272, p = 0.033) was also found in the PCOS subjects.
Conclusion: MMP-9 levels are increased in obese PCOS women and it is associated with NO levels and the duration of infertility.
Key words: Body mass index, Interleukin-10, Nitric oxide, Matrix metalloproteinase-9.
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women in the reproductive age group. The association of testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyroid hormones in obese PCOS women are not clear. Hence, the present study was performed to assess the serum levels of gonadotrophins, testosterone and thyroid hormones in obese and nonobese PCOS women. Materials and methods: Sixty-three patients (41 obese and 22 nonobese) with PCOS were recruited for the study. Serum levels of testosterone, LH, FSH, thyroid stimulating hormone (TSH), free thyroxine (free T4) and free triiodothyronine (free T 3 ) levels were measured. Results: Serum LH (p = 0.040), testosterone (p = 0.010) and free triiodothyronine (p = 0.006) levels were significantly elevated in obese PCOS women as compared to non-obese PCOS women. Both LH (r = 0.478, p = 0.002) and free T3 (r = 0.379, p = 0.036) were correlating positively with body mass index (BMI) in obese PCOS subjects. Testosterone was positively associated with duration of infertility in obese PCOS women (R 2 = 0.187, β = 0.433, p = 0.005) Conclusion: We conclude that LH, testosterone and free T3 levels are increased with increase in BMI among women with PCOS.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.