Objective: The flowers of Millingtonia hortensis were initially screened for the presence of Cu (II) ninhydrin-positive compounds. Purification and characterization of small alpha peptides from the flowers of M. hortensis have been done. Further elucidation of the antimicrobial properties of these small peptides is also taken as part of the work.Methods: Using 80% aqueous ethanol the crude extract was prepared and screening was carried out by a circular paper chromatographic technique. Purification and characterization of small alpha peptides from the flowers of M. hortensis have been done. Further elucidation of the antimicrobial properties of these small peptides by disc diffusion method is also taken as part of the work.Results: Based on the findings of UV-visible spectrophotometer, it is confirmed that the purified compound is a small peptide and might contain glycine, cysteine, and tyrosine or histidine. The result of antimicrobial studies proves the ability of small peptides to function as antimicrobial peptides. Conclusion:It is concluded that the small peptides show an inhibitory effect against various Gram-negative and some Gram-positive bacteria.
Objective: The objective of the current study is toward the green synthesis of silver nanoparticles from the aqueous leaf extracts of Piper betle (BL) and to evaluate its anti-diabetic efficacy. Methods: Silver nanoparticles were prepared with the aqueous leaf extract of Piper betle. Characterization of silver nanoparticles prepared from extracts of Piper betle was done by UV-Visible spectrophotometer absorbance spectrum; Scanning Electron Microscope; and Fourier transform infrared spectrophotometer. The anti-diabetic efficacy was ascertained by inhibition assay of α-amylase activity and glucose diffusion inhibitory study with aqueous leaf extract of Piper betle and silver nanoparticles of Piper betle (BLNP). Results: Based on the findings of spectrophotometer studies, it was confirmed that the silver nanoparticles were generated. High-density silver nanoparticles were synthesized by Piper betle was depicted by scanning electron microscope. The plant extracts (BLE) and its nanoformulation (BLNP) showed a constructive impact on controlling the glucose level by the inhibition of α-amylase activity and glucose diffusion. Conclusion: It was concluded that the Piper betle can be employed as alternative medicine in the efficient management of Diabetes Mellitus.
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