The ASQ identified a developmental deficit of the expected magnitude.

Objective To investigate whether chromosomally normal fetuses with a nuchal translucency (NT)≥

We conclude that, in our cohort of survivors of childhood ALL, prophylactic cranial irradiation of the central nervous system did not have an adverse effect on hypothalamo-pituitary-thyroid function within a median follow-up time of 8 years.

Objectives: Progesterone treatment in second and third trimester of pregnancy has been shown to reduce the risk of preterm delivery in high-risk singleton gestations. This study was conducted to investigate the preventive effect of vaginal progesterone in a large population of twin gestations. Methods: A double-blind, placebo-controlled randomised trial was performed in 17 centres in Denmark and Austria. Women with twin gestations were randomised at 20-24 weeks' gestation to daily treatment with progesterone pessaries or identically looking placebo pessaries until 34 weeks' gestation. Primary outcome was spontaneous delivery or intrauterine death before 34 weeks' gestation. Secondary outcomes were neonatal complications and long-term infant follow-up by Ages and Stages Questionnaire (ASQ) at 6 and 18 months of age. All analyses were performed according to the intention-to-treat principle. Results:A total of 677 women were randomised (334 to the progesterone group and 343 to the placebo group). Two women in the placebo group were lost to follow-up. Baseline characteristics for the progesterone and placebo group were similar. The rate of spontaneous delivery or intrauterine death before 34 weeks was 12.6% in the progesterone group versus 15.5% in the placebo group, odds ratio 0.8 (95% confidence interval 0.5-1.2). Risks of selected maternal and neonatal complications were comparable for the groups. Mean ASQ-score at 6 months was 215 for infants in the progesterone group and 218 for infants in the placebo group (P = 0.45), and 193 and 194, respectively, at 18 months of age (P = 0.89). Conclusions: Progesterone treatment did not prevent preterm delivery in twin gestations. No beneficial or harmful effects were observed in women or infants. OC01.02 A step towards standardization in sonographic assessment of fetal venous system: sequential analysis of five-transverse viewsObjectives: The assessment of the fetal venous system is an essential component to fetal echocardiography as it adds significantly to the complete diagnosis of heart defects. The purpose of this study was to develop a method to standardize and simplify comprehensive examination of the fetal venous system. Methods: Eight hundred and thirty-four fetal congenital cardiovascular anomalies (CVA) were detected between January 2005 and December 2010 in the Division of Maternal Fetal Medicine at Eastern Virginia Medical School. Fetal echocardiograms, which incorporated the assessment of anatomic components of the fetal venous system, were performed between 16 and 39 weeks gestation. Since 2008 the stepwise approach which included evaluation of 5 transverse plans were used: 1. View of the upper abdomen; 2. Coronary sinus view; 3. Four-chamber view; 4. Three-vessel trachea view and 5. View of left brachiocephalic vein. Color and pulse Doppler was used to detect blood flow patterns. Prenatal diagnosis was confirmed in most cases by postnatal echocardiography, angiography, operative findings, or autopsy. Results: Of 834 cases of CVA, 333 (39.9%) were detected be...

Doxapram may have a negative effect on neurodevelopmental outcome.

The phosphate content of the PN influenced plasma phosphate and plasma calcium levels, but increasing the levels of both phosphate and amino acids did not improve weight gain during the first month of life.

Aim: To evaluate the feasibility and validity of a structured telephone interview to assess the development of children born extremely preterm. Methods: The parents of 88 children born with a gestational age below 28 wk admitted to the neonatal intensive care unit (NICU) at Rigshospitalet, Copenhagen, were interviewed by telephone when their child was 1 y of age, corrected for preterm birth. A fully structured questionnaire on psychomotor function was used (Revised Prescreening Developmental Questionnaire (R‐PDQ)). The parents of 30 children born at term without complications were interviewed for comparison. The interview was conducted by NICU staff. To validate the R‐PDQ, parents of 22 children in the preterm group and parents of 19 children in the reference group conducted an Ages and Stages Questionnaire (ASQ) when their children had reached the age of 3–3 y. Results: The R‐PDQ was easy to use by staff and well accepted by parents. The mean score in the preterm group was 14.9 ± 3.9 vs 17.7 ± 2.7 in the term group (p < 0.001). Three children had developmental scores below ‐2 SD. The R‐PDQ score was associated with the ASQ score 2 y later. Conclusion: A structured questionnaire administrated by telephone is an alternative and usable tool for assessing neuro‐developmental deficit in children born extremely preterm. The mean developmental delay in the preterm group compared to the term group (about‐1 SD) was close to expectations.

Introduction: We sought to assess the incidence of severe neurodevelopmental impairment (NDI) in monochorionic twins treated for twin-twin transfusion syndrome (TTTS) and compare it to the incidence in uncomplicated monochorionic twins. Material and Methods: We included TTTS pregnancies treated by fetoscopic selective laser coagulation (FSLC) or umbilical cord occlusion (UCO) in 2004–2015. Primary outcome was severe NDI defined as cerebral palsy, bilateral blindness or bilateral deafness (ICD-10 diagnoses), and severe cognitive and/or motor delay (assessed by the Ages and Stages Questionnaires [ASQ]). Results: A total of 124 children after TTTS and 98 controls were followed up at 25 months of age (SD 11.4). Severe NDI was found in 8.9% of the TTTS children (10.5% [9/86] after FSLC; 5.3% [2/38] after UCO) compared to 3.1% in the control group (p = 0.10). The odds ratio for severe NDI was 1.8 in cases versus controls (p = 0.37). The total ASQ score was significantly lower in the TTTS group than in controls (p = 0.03) after FSLC (p = 0.03) and after UCO (p = 0.14). Discussion: Children after TTTS appear to have a higher risk of severe NDI and score significantly lower on the ASQ compared to monochorionic twins from uncomplicated pregnancies.