The influence of noise and vibration on the development of arterial hypertension in workers employed in adverse working conditions was studied. It is shown that these physical factors of the working environment make a significant contribution to the formation of an increased risk of cardiovascular complications
Background. In recent years, the proportion of young people with functional disorders and diseases of the cardiovascular system has increased, in the formation of which behavioral risk factors play an important role. Aim. To assess the risk of functional disorders developing in young people aged 1825 depending on social status and lifestyle. Material and methods. An observational one-stage uncontrolled study, the object of which was young people aged 1825 years (1978 people), was conducted. The study sample was divided into four groups: working (n=200) and studying (n=313) males, working (n=526) and studying (n=939) females. To assess the relative cardiovascular risk, the groups were divided according to social status, to assess the impairment of adaptive capabilities according to the presence of a behavioral risk factor. Comparison of independent groups was performed using the MannWhitney test. Testing null hypotheses about the absence of differences between the shares was carried out using the 2 test and calculating the odds ratio. Results. Relative cardiovascular risk was found in 21.8% of young people. The chances of risk occurrence were higher in males than in females (p 0.001), in working youth compared to students (p 0.001). The chances of reducing the adaptive capacity of the cardiovascular system were 2.1 times higher in smoking males (p 0.001) and 2.6 times higher in smoking females (p 0.001) compared to non-smoking respondents. In males with excessive alcohol consumption, in females with irregular meals and low physical activity, cases of tension in the mechanisms of adaptation of the cardiovascular system were more often noted (by 1.8; 1.4 and 1.7 times, respectively) compared with control groups. Conclusion. The risk of functional disorders developing was more common in young males than in females, in workers in comparison with students; cigarette smoking in both sexes, alcohol consumption in males, irregular meals and low physical activity in females contributed to a decrease in the reserve capacity of the circulatory system.
Introduction. Occupational asthma has long been considered as a separate, independent disease, but in recent years, more and more attention is paid to its heterogeneity. Molecular genotyping opens up new possibilities in the search for a more targeted and personalized approach to the treatment of occupational asthma, and in the development of an individual strategy for its prevention. The aim of the study was to determine genetic markers of the risk of developing occupational bronchial asthma under exposure to sensitizing substances by assessing polymorphic variants rs2069812 of the IL-5 gene and polymorphic variants rs1837253 of the TSLP gene. Materials and methods. The study was conducted in one hundred seventy patients with various phenotypes of occupational bronchial asthma and 50 people in the control group. Genotyping was performed by real-time polymerase chain reaction using primers and probes developed using the PrimerQuest program (Intergrated DNA Technologies, Inc.). Results. For the first time, genetic markers of the risk for occupational bronchial asthma under exposure to sensitizing substances were identified to include polymorphic variants rs2069812 of the IL-5 gene and polymorphic variants rs1837253 of the TSLP gene. It makes it possible to recommend the determination of these genetic markers during in-depth periodic medical examinations in people working under conditions of exposure to sensitizing and irritating substances in the presence of clinical and functional, immunological changes. Limitations. The study has regional (Samara region) and occupational (detailed working conditions in the studied comparison groups) limitations. Conclusion. The identified marker profiles of occupational asthma genotypes can optimize the approach to diagnosis, treatment, and prevention of this pathology, and expand the range of criteria for predicting the course of the disease.
Introduction. The ”healthy worker effect” (HWE) is currently understood as organized (on the part of the employer) and/or unorganized (self-selection on the part of the worker, due to the functional capabilities and state of health of workers in unfavourable working conditions, is one of the most critical problems when conducting epidemiological studies in occupational pathology. Purpose and objectives. Analysis of the problem in occupational health and safety, the scientific and medical terminology used in the study of the issue of occupational health and safety, taking into account the possible inversion of the effect of exposure to harmful and unfavourable working conditions taking into account this phenomenon, as well as the intensity of occupational health and safety in various professional cohorts. Results. When conducting epidemiological studies in occupational health and occupational pathology, it is necessary to unify the scientific and medical terminology used in researching HWE and consider the possible inversion of exposure to harmful and unfavourable working conditions taking into account this phenomenon. Conclusions. HWE and its intensity in various professional cohorts can indirectly characterize the harmfulness and unfavorability of conditions. HWE, its degree of severity and intensity determine the need for medical and social security and rehabilitation measures in these professional cohorts.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.