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DALK is a successful form of transplantation in stromal corneal disorders with healthy endothelium, with higher long-term graft survival rates and stable ECD 6 months postoperatively. DALK survival rates do not vary significantly over time.

Vitreous traction may not be responsible for blunt trauma-associated retinal lesions and can actually damp shockwaves significantly. Negative pressures associated with multiaxial strain and high strain rates can tear and detach the retina. Differential retinal elasticity may explain the higher tendency toward tearing the macula and vitreous base.

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The use of damage models require a number of material parameters the identification of which should be made, when possible, based on direct measures of the damage that develops in the material. Among the possible experimental techniques to measure the occurrence of ductile damage in metals, the measure of the damage through the degradation of the material Young's modulus has been indicated as one of the more effective technique and used by several authors. In this paper, this technique is critically reviewed highlighting the number of issues that may affect the measure of damage. In particular, the attention is focused in the case where damage process initiates at the onset necking and develops in the post-necking regime where stress, strain and damage are no longer uniform in the gauged section. Since geometry variations alter the reference base length for both stress and strain definition, a procedure based on the use of finite element simulation is proposed in order to account for this effect on the measure of the stiffness loss. The procedure has been applied to two class of metals: a high strength steel and high purity copper.

During dynamic tensile extrusion (DTE) the material is subjected to a complex deformation history, including high strain rates, large strains and elevated temperatures. This technique provides unique means to explore material performance under extreme conditions. In this work, the microstructural evolution of 99.98% commercially pure copper during DTE test was investigated by means of electron backscatter diffraction (EBSD). The investigation was focused on the segment of the extruded jet that remained in the die, since numerical simulation showed that material points along the longitudinal axis of such segment correspond to different stages of a common temperature compensated deformation history. Therefore, post mortem microstructure information extracted at different locations along the centre line is equivalent to in situ real-time measurement during the deformation process. EBSD investigations along the centre line showed a progressive elongation of the grains, and an accompanying development of a strong <001>+<111> dual fibre texture. Meta-dynamic discontinuous dynamic recrystallization (DRX) occurred at larger strains, and it was demonstrated that nucleation occurred during straining, while subsequent grain growth took place during post-deformation cooling in the die. According to strain energy minimization arguments, the recrystallization resulted in an increased <001> texture component. The critical strain for recrystallization was well predicted from a power-law dependence on the Zener-Hollomon parameter, including grain size dependence and a temperature dependent activation energy. In addition, it was shown that <001> and <111> oriented grains develop different dislocation substructures during straining, exhibiting elongated cells/micro-bands and typical cell structures, respectively. The present results also confirm that dynamic tensile ductility increases with decreasing initial grain size as a result of grain refinement and lowering of dislocation and twin densities during DRX.