If you would like to write for this, or any other Emerald publication, then please use our Emerald for Authors service information about how to choose which publication to write for and submission guidelines are available for all. Please visit www.emeraldinsight.com/authors for more information. About Emerald www.emeraldinsight.comEmerald is a global publisher linking research and practice to the benefit of society. The company manages a portfolio of more than 290 journals and over 2,350 books and book series volumes, as well as providing an extensive range of online products and additional customer resources and services.Emerald is both COUNTER 4 and TRANSFER compliant. The organization is a partner of the Committee on Publication Ethics (COPE) and also works with Portico and the LOCKSS initiative for digital archive preservation. ATTITUDES TO LANGUAGE LEARNING 7 W ith the establishment of the Single European Market, British companies may find that foreign language skills are increasingly required.
AbstrakDiabetes mellitus merupakan masalah utama kesehatan di dunia dan prevalensinya selalu meningkat. Pada dosis yang tepat kandungan nikotin dari ekstrak etanol daun tembakau (Nicotiana tabacum) memiliki efek hipoglikemik sehingga berpeluang sebagai terapi alternatif untuk diabetes mellitus. Namun, efeknya pada jaringan adipose penderita diabetes mellitus belum banyak diketahui. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh ekstrak etanol daun tembakau terhadap berat lemak visceral tikus model diabetes mellitus. Pada penelitian ini tikus galur Wistar dibagi menjadi 5 kelompok yaitu kontrol negatif (K-), kelompok tikus model diabetes mellitus (K+), dan tiga kelompok tikus diabetes melitus yang diberi ekstrak etanol daun tembakau 90 (P1), 180 (P2) dan 270 (P3) mg/kgBB/hari per oral selama 28 hari. Hasil penelitian menunjukkan bahwa terdapat penurunan bermakna berat lemak pada semua kelompok tikus DM yang diberi ekstrak daun tembakau dibandingkan dengan tikus DM tanpa terapi maupun tikus normal (p < 0,05). Kesimpulan penelitian adalah pemberian ekstrak etanol daun tembakau menurunkan berat lemak visceral pada tikus model DM. Penurunan berat lemak visceral kemungkinan disebabkan oleh kandungan nikotin dalam ekstrak yang dapat mengaktivasi lipolisis, menghambat lipogenesis, aktivasi thermogenesis, dan penurunan intake makan.Kata kunci: berat lemak visceral, diabetes mellitus, daun tembakau (Nicotiana tabacum). ETHANOL EXTRACT OF Nicotiana tabacum REDUCES THE VISCERAL WEIGHT OF TYPE TWO DIABETIC RATS AbstractDiabetes melllitusis the main health problem in the world and its prevalence is increasing dramatically. Tobacco leaf (Nicotiana tabacum) containing nicotine could be used as an alternative treatment for diabetes mellitus at the right dose. However, its effect on adipose tissue of diabetes mellitus model has not established well. This study aim is to observe the effect of ethanol extract of tobacco leaf to the visceral weight of diabetic rats. Rats were divided into five group normal rats (K-), diabetic rats (K+) and diabetic rats receiving ethanol extract of tobacco leaf at dose 90 (P1), 80 (P2), and 270 (P3) mg/kgBW/day orally for 28 days. Rats were sacrificed and visceral fat was weighed afterward. As the result, visceral fat of diabetic rats was less than the normal rats and diabetic rats treated with ethanol extract of tobacco leaf shown to reduce visceral weight significantly compared to normal rats (p < 0.05). Visceral weight decrement was due to nicotine effect that could induce lipolysis, inhibit lipogenesis, thermogenesis activation, and reduce food intake. Further research is needed to explore Nicotiana tabacum as an alternative treatment for diabetes mellitus.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.