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Genome-Wide Association Study (GWAS) Higher Blood pressure Arthritides Neuropsychiatric conditions Malignancies Lower Anaemias Lipidaemias Ischaemic heart disease Genetically higher central obesity Highlights Variants in HFE and TMPRSS6 are associated with higher liver iron. There is genetic evidence that higher central obesity causes higher liver iron. Liver iron variants are not organ specific and associate with multiple diseases.

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Introduction: Patients with type 1 diabetes mellitus (T1DM) may present with diabetic ketoacidosis (DKA) at diagnosis. Young age (especially < 2 years), diagnostic error, delayed treatment, and residence in a country with low T1DM prevalence are DKA risk factors. Objectives: We studied the initial clinical presentations and DKA prevention in T1DM patients.Methods: We accessed medical records of T1DM patients who were treated in our hospital in July 2018. We noted their age at diagnosis, symptoms, and duration of symptoms. We then classified patients according to DKA severity and noted their chief complaints at the first visit percentages of patients who had symptoms characteristic of T1DM, and blood glucose, glycated hemoglobin (HbA1c), and blood C-peptide levels.Results: We treated 49 patients (aged 14.2±5.9 years; 18 male, 31 female). We assessed initial clinical presentations in 45 patients,

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