ISPAD Clinical Practice Consensus Guidelines 2006?2007 Definition, epidemiology and classification

Craig, Maria E.; Hattersley, Andrew; Donaghue, Kim C.

doi:10.1111/j.1399-5448.2006.00216.x

Cited by 69 publications

(43 citation statements)

References 76 publications

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“…The date of the first insulin injection was considered to be the date of diagnosis. Data collected were baseline data (including ethnicity and family history of any type of diabetes in first-degree relatives), biochemical data at onset ( [18,27]. Blood glucose >11 mmol/l (∼200 mg/dl), ketonuria and/or ketonaemia, and a venous pH value <7.30 marked the biochemical criterion for DKA [27].…”

Section: Methodsmentioning

confidence: 99%

“…These populationbased surveys represent countries with a high annual background incidence of type 1 diabetes comparable with that of Denmark [18]. Elding Larsson et al, who followed-up and screened children genetically at risk of diabetes for diabetesspecific autoantibodies in a multinational study, found that participation in the study was associated with reduced risk of DKA [19].…”

Section: Introductionmentioning

confidence: 99%

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Diabetic ketoacidosis at the onset of type 1 diabetes is associated with future HbA1c levels

et al. 2013

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Aims/hypothesis We investigated the long-term impact of diabetic ketoacidosis (DKA) at onset on metabolic regulation and residual beta cell function in a Danish population with type 1 diabetes. Methods The study is based on data from DanDiabKids, a Danish national diabetes register for children. The register provides clinical and biochemical data on patients with type 1 diabetes diagnosed in 1996-2009 and then followed-up until 1 January 2012. Repeated-measurement models were used as statistical methods.Results The study population comprised 2,964 children <18 years. The prevalence of DKA at diagnosis was 17.9%. Of the total subjects, 8.3% had mild, 7.9% had moderate and 1.7% had severe DKA. DKA (moderate and severe) was associated with increased HbA 1c (%) levels (0.24; 95% CI 0.11, 0.36; p=0.0003) and increased insulin dose-adjusted HbA 1c (IDAA 1c , 0.51; 95% CI 0.31, 0.70; p<0.0001) during followup, after adjustment for covariates. Children without a family history of diabetes were more likely to present with DKA (19.2% vs 8.8%, p<0.0001); however, these children had a lower HbA 1c (%) level over time (−0.35; 95% CI −0.46, −0.24; p<0.0001). Continuous subcutaneous insulin infusion (CSII) was associated with a long-term reduction in HbA 1c , changing the effect of DKA, after adjustment for covariates (p<0.0001). Conclusions/interpretation DKA at diagnosis was associated with poor long-term metabolic regulation and residual beta cell function as assessed by HbA 1c and IDAA 1c, respectively; however, CSII treatment was associated with improvement in glycaemic regulation and residual beta cell function, changing the effect of DKA at onset in our population.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diabetic ketoacidosis at the onset of type 1 diabetes is associated with future HbA1c levels

et al. 2013

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“…Diagnostic criteria for childhood diabetes were according to ISPAD criteria for children and adolescents (ISPAD Clinical Practice Consensus Guidelines 2006–2007) [16]. Regular meetings and professional certified education were offered to the participating pediatricians.…”

Section: Methodsmentioning

confidence: 99%

“…The number of type 2 diabetes cases diagnosed is subject to regional aspects and ethnic origin. Type 2 diabetes is more frequently found in African-American children and adolescents and in offspring of Pima Indians compared to children and adolescents of Caucasian origin [16,17,18,19]. Epidemiological data on other types of diabetes in childhood is scare.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of Childhood Diabetes in Children Aged Less than 15 Years and Its Clinical and Metabolic Characteristics at the Time of Diagnosis: Data from the Childhood Diabetes Registry of Saxony, Germany

Galler¹,

Stange

Müller

et al. 2010

Horm Res Paediatr

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Aims: The Childhood Diabetes Registry in Saxony, Germany, examined the incidence and metabolic characteristics of childhood diabetes. Methods: In the federal state of Saxony, newly diagnosed cases of diabetes in children and adolescents aged less than 15 years were registered continuously from 1999 until 2008. Family history, date of diagnosis, clinical and laboratory parameters were obtained. Reported cases were ascertained by public health departments as an independent data source and verified using the capture- recapture method. Results: A total of 865 children and adolescents with newly diagnosed diabetes were registered in Saxony. About 96% of them were classified as having type 1 diabetes, 0.6% had type 2 diabetes, 2.4% had maturity-onset diabetes of the young (MODY), and 1.4% had other types of diabetes. The age-standardized incidence rate of type 1 diabetes was estimated at 17.5 per 100,000 children per year. Completeness of ascertainment as calculated by the capture-recapture method amounted to 93.6%. At the time of diagnosis, 27.1% of children with type 1 diabetes had ketoacidosis, 1.5% had a blood pH <7.0, and 1.1% were unconscious. Conclusion: The registry provided data about the incidence rates and clinical presentation of childhood diabetes in a defined German population. We observed higher incidence rates compared to previous surveys.

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Methodology of Evidence‐based Medicine

Allgrove¹

2007

Evidence‐based Paediatric and Adolescent Diabetes

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ISPAD Clinical Practice Consensus Guidelines 2006?2007 Definition, epidemiology and classification

Cited by 69 publications

References 76 publications

Diabetic ketoacidosis at the onset of type 1 diabetes is associated with future HbA1c levels

Diabetic ketoacidosis at the onset of type 1 diabetes is associated with future HbA1c levels

Incidence of Childhood Diabetes in Children Aged Less than 15 Years and Its Clinical and Metabolic Characteristics at the Time of Diagnosis: Data from the Childhood Diabetes Registry of Saxony, Germany

Methodology of Evidence‐based Medicine

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