Objective: To assess the effect of prayer on blood pressure, heart rate and respiratory rate in patients with chronic kidney disease and learn their perception of the intervention. Method: A randomized controlled trial, double blind with a sample of volunteers, randomized into an intervention group (n=42) and a control group (n=37). Questionnaires addressing socio-demographic, clinical and spiritual characteristics and the Duke University Religious Index were applied. Blood pressure, heart rate and respiratory rate were measured. The prayer was conducted at three different moments on alternating weeks. The qualitative data were organized and analyzed through Thematic Analysis. Results: The sample consisted of 95 randomized volunteers. In the intra-group analysis, a statistically significant reduction (P<0001) of blood pressure, heart rate and respiratory rate was observed in all evaluations of the people who were prayed for. The qualitative analysis resulted in the themes Prayer in a "Place of Suffering" and Positive Evaluation and in the sub-themes Relief from Suffering, Hope for Improvement, and Coping with Hemodialysis. Conclusion: Prayer reduced blood pressure, heart rate and respiratory rate in patients who suffer from chronic kidney disease, and the volunteers' evaluation of the intervention was positive. Brazilian Clinical Trials Registry: RBR-2zv39y.

Objetivo: Evaluar la variación temporal y la correlación entre elbienestar espiritual y el afrontamiento religioso/espiritual en personas con insuficiencia renal crónica sometidas a hemodiálisis.Metodología: Estudio descriptivo, analítico y longitudinal. La muestra inicial contó con 118 participantes, pero al final de la recopilación de datos hubo una pérdida de 31, lo que redujo la muestra a 87. Se aplicaron mediante entrevistas el cuestionariosociodemográfico y clínico, la Escala de Coping Religioso/Espiritual Breve (cre-Breve) y la Escala de Bem-estarEspiritual (ebe). La recopilación de datos se realizó en tres etapas, con intervalos frecuentes de dos meses.Resultados: Se encontró que las personas con insuficiencia renal crónica sometidas a hemodiálisis suelen recurrir al afrontamiento religioso y espiritual. La media positiva de cre fuede 3,34, lo que reflejó una alta puntuación. Por su parte, el ebe total y el ebe religioso se asociaron significativamente con la importancia que se le da a la religión/espiritualidad (p < 0,001).Conclusiones: Los pacientes con insuficiencia renal crónica sometidos a hemodiálisis utilizan el afrontamiento religioso/espiritual de manera positiva y significativa; así mismo, consideran importante la religión/espiritualidad en sus vidas.

Dengue is the most prevalent arthropod-borne viral illness in humans worldwide. Single-nucleotide polymorphisms (SNPs) in genes involved in the immune response, such as dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), IgG Fc receptor II-A (FcγRIIa), vitamin D receptor (VDR), and tumor necrosis factor alpha (TNF-α), were previously reported to be associated with susceptibility to dengue disease in different human populations. Therefore, due to the relevant association of host immune and genetic status with disease susceptibility/severity of dengue, this work aims to verify the frequency of anti-dengue virus antibodies and some dengue-associated risk SNPs in a population in Minas Gerais State, Southeast Brazil. A total of 1560 individuals were genotyped for polymorphisms in DC-SIGN (rs4804803), FcγRIIa (rs1801274), VDR (rs7975232), and TNF-α (rs1800629). The presence of anti-dengue antibodies (IgM and/or IgG) in these samples was also assayed. Anti-dengue antibodies were detected at an overall frequency of 16.86%, indicating a virus infection in asymptomatic individuals. The genotypic frequencies of all SNPs studied did not differ between the asymptomatic and control groups. Regarding the allelic frequencies of the four SNPs analyzed, a higher frequency was detected of the G allele of FcγRIIa/rs1801274 in the asymptomatic individuals when compared to that in the control group (p = 0.03). Therefore, the results showed a high prevalence of asymptomatic individuals in Minas Gerais State, with a potential association between the presence of the G allele of FcγRIIa/rs1801274 and protection against symptomatic disease.