The in vitro conversion of [4-14C] cholesterol1) to steroid hormones was studied in 1 normal, 1 adenomatous and 2 hyperplastic, surgically resected, human adrenals. The degree of overall conversion per gram of tissue was similar (4.4\p=n-\5.6 %) in NADPH-supplemented homogenates from normal or moderately hyperactive adrenals; a 2-fold increase was found in a markedly hyperfunctioning gland. Only labelled cortisol, * Address reprint requests to A. is the abbreviation for adrenocorticotrophic hormone.

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