The Adrenal Functional Unit: A Hypothesis

Carballeira, Andrés; Fishman, Lawrence M.

doi:10.1353/pbm.1980.0064

Cited by 27 publications

(10 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As seen in most vertebrates, steroid-secreting and chromaffin tissue in the adrenal gland are located together in spite of their different embryological origin, and it is now evident that cortex and medulla are functionally interlinked (Carballeira and Fishman, 1980;Hinson, 1990).…”

Section: Discussionmentioning

confidence: 99%

Modulation of autotransplanted adrenal gland by endothelin‐1: A morphological and biochemical study

et al. 1996

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Modulation of autotransplanted adrenal gland by endothelin‐1: A morphological and biochemical study

et al. 1996

View full text Add to dashboard Cite

“…Regulatory mechanisms common to both the cortex and medulla are being investigated. In fact, recent data brings new findings in this subject, and it is now evident that the products of each of these tissues influence the function of the other (Carballeira and Fishman, 1980;Hinson, 1990).…”

Section: Figsmentioning

confidence: 98%

Autotransplantation of the adrenal cortex: A morphological and autoradiographic study

Vendeira¹,

Magalhães²,

Magalhães³

1992

Anat. Rec.

View full text Add to dashboard Cite

A morphological and autoradiographic study was made of the adrenal gland of adult male rats after autotransplantation. The simple technique involved placement of pieces of the adrenal gland in a dorsal plane between the skin and muscle. Animals for morphological studies were sacrificed at 2, 3, 4, 7, 15, 30, 90, and 180 days after autotransplantation. Those for autoradiographic studies were sacrificed at 2, 3, 7, and 15 days after autotransplantation, with 3H-thymidine being administered intraperitoneally 2 h before sacrifice. Sham-operated animals were used as controls. The majority of glandular adrenal cells suffered necrosis in the first days (2 and 3) after autotransplantation. Up until 15 days and after revascularization, morphological features of the cells were compatible with protein synthesis exhibiting a developed RER, scarce SER, and mitochondria with tubular and lamellar cristae. These data may correspond to a proliferative phase of glandular cells. At day 15, cells showed morphological signs of steroidogenic activity (mitochondria with vesicular cristae, increase of SER), and at day 30, an increased number of microvilli were seen. Between 30 and 90 days zonation of the adrenal was evident with glomerulosa, fasciculata, and reticular zones readily apparent. The quantitative analysis showed a significant increase of the volumetric density of mitochondria and microvilli between the days 7 and 30. Autoradiographic studies showed an intense labelling of fibroblast-like cells at days 2 and 3 and of glandular cells at days 7 and 15, which was confirmed by the quantitative studies. Corticosterone in autotransplanted animals decreased during the first 15 days, but after 30 days the values were similar to controls. The model reported here seems to be good for study of the regeneration of the adrenal gland and can be a simple, useful, and reproducible method for adrenal transplantation.

show abstract

“…It has been known for quite some time that adrenocortical steroids have a regulatory function upon the medullary enzymes which are involved in the synthesis of catecholamines (Axelrod and Reisine, 1984;Carballeira and Fishman, 1980). In late embryological, neonatal, and adult chromaffin cells the expression of the phenylethanolamin-N-methyl transferase (PNMT) is regulated by glucocorticoids (Bohn et al, 1981;Ehrlich et al, 1989;Grothe et al, 1985;Teitelman et al, 1982;Wurtman and Axelrod, 1966).…”

Section: Physiological Relevance Ofmentioning

confidence: 99%

Morphological and functional studies of the paracrine interaction between cortex and medulla in the adrenal gland

Bornstein

Ehrhart‐Bornstein

Scherbaum

1997

Microsc. Res. Tech.

View full text Add to dashboard Cite

The Adrenal Functional Unit: A Hypothesis

Cited by 27 publications

References 63 publications

Modulation of autotransplanted adrenal gland by endothelin‐1: A morphological and biochemical study

Modulation of autotransplanted adrenal gland by endothelin‐1: A morphological and biochemical study

Autotransplantation of the adrenal cortex: A morphological and autoradiographic study

Morphological and functional studies of the paracrine interaction between cortex and medulla in the adrenal gland

Contact Info

Product

Resources

About