agradecimentos pela orientação, amizade e constante incentivo durante todas as etapas deste trabalho. À Professora Doutora Érika R. M. Kedor-Hackmann, pelo convívio e sugestões no transcorrer do trabalho. Ao Professor Doutor Anil K. Singh, pelo convívio e preciosas sugestões no transcorrer do trabalho. Ao Professor Doutor Jorge S. Martins, pelo convívio no transcorrer do trabalho. Aos colegas de Pós-Graduação, em especial a Andréia, Daniella, Elizângela, Regina, Fátima, Ixis, Nájla e Tatiana, pelo convívio e cooperação. À Iria e Regina, pela colaboração no desenvolvimento deste trabalho. À minha família, em especial aos meus pais, pela compreensão, apoio e estímulo durante todos estes anos em São Paulo.
Recebido em 2/3/05; aceito em 5/8/05; publicado na web em 20/1/06 Zidovudine (AZT) and stavudine (D4T) are nucleoside reverse transcriptase inhibitors extensively used in human immunodeficiency virus (HIV) infected patients. In order to evaluate the quality of these drugs, two stability indicating HPLC methods were developed. The validated methods were applied in quantitative determination of AZT, D4T and their induced degradation products in capsule preparations. The stability studies were conducted at controlled temperature and relative humidity conditions based on the International Conference on Harmonization stability studies protocol for Zone IV areas. Easy sample preparation and low-cost make these methods especially useful for quality control and stability studies of AZT and D4T in drug products.
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