This chapter focuses on reimagining our relationship to the dancing body, inviting connection to self, others, and the natural world. Body systems and earth systems are seen as intricately interconnected, and dance as an essential way to experience this connection. Utilizing personal narrative, scientific research, experiential exercises, and visual imagery as modes of inquiry enables one to create the conditions for wellbeing through movement. The goal is to bind subjective experience with a scientific foundation through embodied scholarship. This multifaceted approach enhances the reader’s receptivity to discovery and discernment, encouraging agency in creative projects, intercultural communication, and daily life through dance. Attention is given to the science of perception, including tools for balancing the autonomic nervous system to support healing and creative thinking. Throughout, we foster positive responses to challenging social and environmental conditions through moving, dancing, performing, and writing—celebrating the intrinsic intelligence of the body.

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Glioblastoma Multiforme (GBM) is the most aggressive and most common primary malignant brain tumor. The age of GBM patients is considered as one of the disease's negative prognostic factors and the mean age of diagnosis is 62 years. A promising approach to preventing both GBM and aging is to identify new potential therapeutic targets that are associated with both conditions as concurrent drivers. In this work, we present a multi-angled approach of identifying targets, which takes into account not only the disease-related genes but also the ones important in aging. For this purpose, we developed three strategies of target identification using the results of correlation analysis augmented with survival data, differences in expression levels and previously published information of aging-related genes. Several studies have recently validated the robustness and applicability of AI-driven computational methods for target identification in both cancer and aging-related diseases. Therefore, we leveraged the AI predictive power of the PandaOmics TargetID engine in order to rank the resulting target hypotheses and prioritize the most promising therapeutic gene targets. We propose cyclic nucleotide gated channel subunit alpha 3 (CNGA3), glutamate dehydrogenase 1 (GLUD1) and sirtuin 1 (SIRT1) as potential novel dual-purpose therapeutic targets to treat aging and GBM.

ing, and even laboratory genetics. With respect to CHEK2 variant carriers, NCCN Guidelines state that "The risks for most missense variants are unclear but for some pathogenic/likely pathogenic (P/LP) variants, such as Ile157Thr, the risk for breast cancer (BC) appears to be lower [than for frameshift pathogenic/likely pathogenic variants]. Management should be based on best estimates of cancer risk for the specific pathogenic/ likely pathogenic variant." This implies that CHEK2 p.Ile157Thr variant is considered by the NCCN Guidelines panel members to be classified as P/LP, and should be reported for risk management (contrary to variants classified as benign/likely benign [B/LB]).Without speculations on variant classification in accordance with American College of Medical Genetics and Genomics/Sherloc guidelines, 2,3 we may state that, first, this variant may be considered as a rare polymorphism (minor allele frequency [MAF] based on ExAC project 0.40%; in comparison: highest MAF across BRCA1/2 P/LP variants at 0.026% [ExAC] for BRCA2 p.Ser1982fs and the second highest MAF at 0.0067% [ExAC] for BRCA2 p.Cys61Gly, which are 16 times and 60 times higher than MAF for the CHEK2 p.Ile157Thr variant, respectively). Second, risk for BC associated with this variant appears to be low (as noted by current NCCN Guidelines, odds ratio [OR] for BC, 1.58; 95% CI, 1.42-1.75). 4 These put this variant in line with other rare polymorphisms, which, despite B/LB classification (as of majority of CLINVAR submissions), may confer increased risk for BC (though significantly lower, compared with P/LP variants of the same gene). For example, BRCA2

This article explores seaweed from biological, historical and aesthetic perspectives through performance. Dancing in wild places: Seaweed and ocean health is a 40-minute project based on travels and dancing at seven seaweed sites internationally including California, France, Ireland, Iceland, Nova Scotia, Florida and the Florida Keys. Discussion about the challenges and opportunities of linking artmaking and environmental projects is interwoven. A multi-layered format combines informational narratives with performance texts, video links and visual images, amplifying the interconnectedness of ecosystems and including humans as part of nature. The process engages the ecotone between knowing and not knowing, a place of heightened possibility. Amidst current environmental challenges, seaweed reminds us that every discipline has a role to play in the restoration of ocean health. Dance helps us feel; as we feel we care – becoming caretakers of Earth, caretakers of body. Movement is primary in knowing ourselves and the world. Our bodies remember.