A b s t r a c tSkin aging has become an area of increasing research interest in dermatovenerology. Changes in the skin associated with aging can be detected by high -frequency 20 MHz ultrasonography, which is a useful diagnostic technique allowing reliable imaging of cutaneous and superficial subcutaneous structures.Skin thickness is considered an objective parameter providing assessment of the influence of endogenous or exogenous factors, such as ultraviolet (UV) or infrared (IR) rays. Except for the changes in the skin thickness, there are also specific structural changes in the dermis of older subjects -subepidermal low echogenic band (SLEB) -that is a manifestation of photoaging severity. The main aim of this study was to identify and characterize the specific ultrasonographic changes of the cutaneous structure related to age and degree of photo exposure (the presence and measurement of SLEB).

We report a 2-year-old patient with Netherton syndrome presenting with generalized exfoliative erythroderma, ichthyosiform dermatitis, trichorrhexis invaginata, hypernatremic dehydration, failure to thrive, and recurrent respiratory infections. Molecular analysis of SPINK5 identified a novel mutation (c.1530CA). Our case report also verifies and supports the safety and efficacy of subcutaneous immunoglobulin substitution in chronic generalized skin disorders associated with primary immunodeficiencies such as Netherton syndrome.

A b s t r a c tInternal malignancy may be presented in the form of paraneoplastic syndromes, which may indicate either formation or recurrence of a previously treated malignancy. Furthermore cutaneous paraneoplastic disorders often precede a diagnosis of cancer. We present 2 unique case reports with cutaneous paraneoplastic manifestations. The first one describes a patient with sudden progression of long-term stabilized morphea in connection with newly diagnosed hepatocellular carcinoma (HCC). The second one describes female patient with breast cancer preceded by the development of extragenital lichen sclerosus (LS) with typical sclerotic lesions and hemorrhagic bullae.

Background Atopic dermatitis (AD) is the most common cause of eczema. The skin condition affects millions of people worldwide. Severe cases of AD demand systemic treatment, but most AD cases rely on local therapy with topical corticosteroids, emollients, and moisturizing agents to alleviate eczema. Commonly, derma‐cosmetics with a pH around 5.5 are used to treat eczematous lesions (EL). However, evidence is currently amassing that the use of mildly alkaline topical creams is beneficial for AD‐related eczema treatment because of its effect on the inflammation in the skin. Aims To test an alkaline two‐phase care concept for the treatment of eczema. Patients/Methods An open‐label study of 25 patients with eczema associated with mild AD. Patients were treated with Alkaline Build Up Caring Cream INTENSIVE and Alkaline Build Up Caring Cream PLUS+ (both Siriderma®) for eight weeks. Dermatological, biochemical, and questionnaire‐based examinations were conducted prior to the trial and after its completion. Results Topical administration of slightly alkaline creams led to small and statistically insignificant increases of skin pH. Clinical examination at the end of the observation period revealed a significant decrease of total eczematous‐affected skin area, a significant decrease in average severity scores of EL, and significant improvements in patient‐reported outcome parameters. Blood tests did not reveal any significant changes, except for small but significant increases in IL‐8 and monocytes. Conclusion Mildly alkaline topical creams seem to provide soothing effects on eczema‐related skin inflammation and thus might contribute to treatment of local symptoms of eczema in patients with mild AD.

High-frequency skin ultrasonography using Dermascan C, manufactured by Cortex Technology, is an important part of modern diagnostic procedure of various skin diseases. It has been used in dermatology since 1979, when it was first used for the measurement of cutaneous thickness. Ultrasonography is a universal, painless, low-risk and non-invasive procedure that can easily be performed and repeated. It provides real-time visual information about the processes in the skin. This technique has grown to become frequent imaging method in dermatology. Skin ultrasonography is usually applied in the assessment of skin tumours, inflammatory or fibrosing skin diseases. The main application of ultrasonography in dermatovenerology is a preoperative thickness measurement of malignant melanoma. There is an excellent correlation between ultrasonographic and histological measurements of melanomas thickness. Moreover, information about the lesion quality and the inner structure can be obtained. In this article authors present the possibility of using high-frequency 20 MHz ultrasonography in dermatovenerology.