Cutaneous Paraneoplastic Manifestation (Morphea, Lichen Sclerosus) – Two Case Reports

Abstract

A b s t r a c tInternal malignancy may be presented in the form of paraneoplastic syndromes, which may indicate either formation or recurrence of a previously treated malignancy. Furthermore cutaneous paraneoplastic disorders often precede a diagnosis of cancer. We present 2 unique case reports with cutaneous paraneoplastic manifestations. The first one describes a patient with sudden progression of long-term stabilized morphea in connection with newly diagnosed hepatocellular carcinoma (HCC). The second one describes female patient with breast cancer preceded by the development of extragenital lichen sclerosus (LS) with typical sclerotic lesions and hemorrhagic bullae.

Morphea in two patients after being infected to and being vaccinated against SARS‐CoV‐2 infection

“…Moreover, some malignancies have been first presented with cutaneous manifestations, such as morphea. 35 , 36 , 37 Accordingly, we performed a thorough work‐up to detect any malignancies being presented with morphea as a paraneoplastic sign. Therefore, we attributed the condition to infection and vaccination.…”

Morphea in two patients after being infected to and being vaccinated against SARS-CoV-2 infection

“…We evaluated both of the patients for autoimmune rheumatologic diseases, autoimmune thyroiditis, HCV and HBV, and IgE levels, none of which turned positive. Moreover, some malignancies have been first presented with cutaneous manifestations, such as morphea (35)(36)(37). Accordingly, we performed a thorough work-up to detect any malignancies being presented with morphea as a paraneoplastic sign.…”

Palmar lichen sclerosus et atrophicus

“…Given the patient's history of smoking, the rare atypical presentation of this condition, and one case report of breast cancer preceded by extragenital LS&A, 6 age-appropriate malignancy screening was pursued to rule out an atypical paraneoplastic phenomenon. Paraneoplastic workup including mammogram, colonoscopy, and chest radiograph only found underlying chronic obstructive pulmonary disease.…”