Introduction. Melanoma is the most dangerous form of skin cancer. Morbidity from melanoma is increasing every year. Previous studies have revealed that there are some demographic and clinical factors having effect on melanoma survival prognosis.Aim of the study. Purpose of our study was to assess melanoma survival depending on prognostic factors, such as age, sex, stage, depth, histology and anatomical site.Materials and methods. We investigated melanoma-specific survival up to 10 years in 85 primary cases of melanoma from diagnosis at the National Cancer Institute in 2006. Analysis was performed for one-, five-, and ten-year survival. The data were processed with Microsoft Excel, data analysis was conducted using SPSS® software.Results. Melanomas diagnosed at stage IV or thicker than 4.00 mm had lower survival (five-year survival: 12.5% and 26.66%, respectively). A significant survival difference was observed among the different stages (p = 0.003) and different depths (p = 0.049) of melanoma. Ten-year survival was 32% for men and 61% for women, but melanoma-specific survival dependent on sex did not have a statistically significant difference (p = 0.121). In persons diagnosed at the age of 65 or older, ten-year survival was lower than in those of 40-64 years of age and in the age group of 15-39 years (44.44% and 26.66%, respectively), but melanoma-specific survival in different age groups did not have a statistically significant difference (p = 0.455). Back/breast skin melanoma had lower ten-year survival (37.03%) than other anatomic sites. Nodular melanoma had the poorest five-year and ten-year melanoma-specific survival among histological subtypes (51.67% and 38.75%). The differences between melanoma localizations (p = 0.457) and histological types (p = 0.364) were not statistically significant.Conclusions. Lower melanoma-specific survival rates were observed among patients diagnosed at a late stage, older age, and when melanomas were thicker than 4.00 mm. Female and younger patients had better melanoma-specific survival than men and older people, and these differences were statistically significant. Melanoma diagnosed at an early stage and of a small depth had higher survival rates. Back/breast skin melanoma had poorer prognosis than other anatomic sites. Nodular melanoma had the lowest melanoma-specific survival, while superficial spreading or lentigo maligna had the best prognosis among histological subtypes. However, differences in melanoma survival in different sex and age groups, localizations and histological types were not statistically significant.

OBJECTIVES To determine the frequency of contact sensitization among patients with chronic leg ulcers; to identify the most common allergens; and to examine possible relationships to ulcer duration, itching, exudate, and leg eczema. METHODS Researchers conducted a 5-year retrospective analysis of 145 patients diagnosed with chronic leg ulcers who underwent skin patch testing with S-1000, LU-1000, and the commonly used dressing and antiseptic series. RESULTS Investigators included 88 females (60.7%) aged 64 ± 15.1 years and 57 males (39.3%) aged 61 ± 16.4 years. Of these, 62.8% (n = 91) of patients were sensitized to at least one substance (2.6 ± 1.4 allergens on average). The most common allergens were benzalkonium chloride (18.6% [n = 27]), balsam of Peru (17.9% [n = 26]), and povidone-iodine 10% (17.2% [n = 25]). Finally, 40% (n = 58) of patients presented with pruritus around the ulcer, which was strongly associated with a positive patch test reaction (74.1% [n = 43] vs 55.2% [n = 48]; P = .021) and polysensitization (3.5 sensitivities [95% confidence interval, 2.4–4.6] vs 2 [95% confidence interval, 1.2–2.8]). CONCLUSIONS Contact sensitization is very common in patients with chronic leg ulcers, and pruritus around the ulcer is associated with contact allergy as well as polysensitization.

Aknė yra lėtinė uždegiminė pilosebacinio (riebalų liaukos – plauko folikulo) vieneto odos liga. Daugelis studijų parodė, kad aknė turi didelės įtakos pacientų savęs vertinimui, kasdieninei veiklai ir gyvenimo kokybei. 2015-2016 m. Vilniaus universiteto ligoninės Santaros klinikų (VUL SK) Dermatovenerologijos centre, keturiose Vilniaus miesto privačiose klinikose ir dviejuose kosmetologijos kabinetuose atliktas anoniminis anketinis tyrimas. Akne sergantys pacientai užpildė originalią anketą, kurioje pateikta 15 sudėtinių klausimų ir Dermatologinio gyvenimo kokybės vertinimo klausimynas. Duomenys apdoroti Microsoft Exel programa, duomenų analizė atlikta SPSS® programa. Į tyrimą įtraukti 262 respondentai, sergantieji akne, iš kurių 180 moterų (68,7 proc.) ir 82 vyrai (31,3 proc.). Vidutinis aknės pasireiškimo amžius tarp tiriamųjų – 14,89 (± 3,43) metai. Dermatologinio gyvenimo kokybės indekso anketos (DGKIA) balai išsidėstė nuo 0 iki 28. DGKI bendras vidurkis – 8,96 (± 5,72), moterų grupėje – 9,45 (± 5,56), vyrų – 7,74 (± 5,12), statistiškai reikšmingo skirtumo tarp lyčių nenustatyta (p=0,23). Reikšmingo statistinio skirtumo tarp amžiaus grupių taip pat nebuvo nustatyta (p=0,177). Dažniausiai aknės įtaka žmogaus gyvenimo kokybei buvo vidutinė (33,2 proc.). Rečiausiai aknė turėjo labai didelę įtaką žmogaus gyvenimo kokybei (3,8 proc.). Daugiausia pacientų dėl aknės jautėsi nusiminę, susigėdę, drovūs ar liūdni (19,7 proc.). Mažiausiai aknė trukdė seksualiniams santykiams (5,27 proc.). Aknė dažniausiai pasireiškia jauniems vidutiniškai 21 metų amžiaus žmonėms. Dažniausiai aknė turėjo vidutinę įtaką žmogaus gyvenimo kokybei. Rečiausiai aknė turėjo labai didelę įtaką žmogaus gyvenimo kokybei. Dauguma pacientų dėl aknės jautėsi nusiminę, susigėdę, drovūs ar liūdni. Mažiausiai aknė trukdė seksualiniams santykiams.