No abstract

Purpose -This article aims to describe the development of industrialised house-building (IHB) to increase the understanding of the field. Design/methodology/approach -The study is based on an extensive literature study and a case study with three companies, studied between 2005 and 2013 which enabled an in-depth knowledge about the companies' development within IHB. Interviews, observations and document studies are the main sources of information in the case studies. Findings -IHB is a complex field, consisting of several constructs that need to be integrated and continuously developed. Development of structured technical building systems has been central to the development of IHB along with developed production methods and processes. The interest in organisational fit or adaptation to industrialisation and strategy concerning business, production and products is increasing. This implies that IHB needs to be managed strategically and not on a building project level. Practical implications -The article gives an orientation on how leading companies have structured and organised their work within industrialisation, giving valuable advice to practitioners with interest in the field. Originality/value -This article describes the development of IHB based on studies of literature and three Swedish IHB companies' development. This provides an aggregated view of the field's emergence and unique information about the studied companies' development.

The objective of the present study was to assess the relationship between the amount of lactate accumulated during complete ischaemia and the ensuing changes in extra- and intracellular pH (pHe and pHi, respectively). The preischaemic plasma glucose concentration of anaesthetized rats was varied by administration of glucose or insulin, pHe was determined in neocortex with ion-sensitive microelectrodes, and tissue lactate and CO2 contents were measured, tissue CO2 tension being known from separate experiments. The experiments were carried out in both normocapnic [arterial CO2 tension (PaCO2) approximately 40 mm Hg] and hypercapnic (PaCO2 approximately 80 mm Hg) animals. Irrespective of the preischaemic CO2 tension, DeltapHe was linearly related to tissue lactate content. Depending on the preischaemic glucose concentration, DeltapHe varied from <0.4 to >1.4 units. The results thus fail to confirm previous results that the changes in pHe describe two plateau functions (DeltapHe approximately 0.5 and 1.1, respectively), with a transition zone at tissue lactate contents of 17 - 20 mmol kg-1. Changes in pHi given in this study are based on the assumption of a uniform intracellular space. The pHi changed from a normal value of approximately 7.0 to 6.5, 6.1 and 5.8 at tissue lactate contents of 10, 20 and 30 mmol kg-1. The intrinsic (non-bicarbonate) buffer capacity, derived from these figures, was 23 mmol kg-1 pH-1. Some differences in pH and in HCO3- concentration between extra- and intracellular fluids persisted in the ischaemic tissue. These differences were probably caused by a persisting membrane potential in the ischaemic cells.

On the basis of data showing a bimodal distribution of values for extracellular pH (pHe), and a discontinuous delta PCO2/delta lactate relationship, Kraig et al. (1986) proposed that H+ is grossly compartmentalized between neurons and glia in the ischemic brain. We measured delta pHe during ischemia, varying ischemic lactate contents between 9 and 38 mmol kg-1. No bimodal distribution was found, but delta pHe varied linearly with lactate content. Because we have also failed to record a discontinuous delta PCO2/delta lactate relationship, we conclude that major compartmentation of H+ does not occur during ischemia.