We
present the optical sensing of phthalate esters (PAEs), a group of
endocrine-disrupting chemicals. The sensing takes place as changes
in the fluorescence emission intensity of aminopyrene covalently bound
to the organic ligands of the metal–organic framework compound
ZIF-8. In the presence of PAEs, a quenching of the fluorescence emission
is observed. We evaluated strategies to engineer colloidal size distribution
of the sensing particles to optimize the sensory response to PAEs.
A thorough characterization of the modified ZIF-8 nanoparticles included
powder X-ray diffractometry, transmission electron microscopy, high-performance
liquid chromatography, and photophysical characterization. The presented
capability of the fluorophore-functionalized ZIF-8 to sense PAEs complements
established methods such as chromatography-based procedures, which
cannot be used on-site and paves the way for future developments such
as hand-held quick sensing devices.
The present study investigates early stages of ZIF-8 crystallization up to 5 minutes post mixing of precursor solutions. Dispersive X-ray Absorption Spectroscopy (DXAS) provides a refined understanding of the evolution...
Zeolitic imidazolate framework (ZIF) hybrid fluorescent nanoparticles and ZIF antibody conjugates have been synthesized, characterized, and employed in lateral-flow immunoassay (LFIA). The bright fluorescence of the conjugates and the possibility to tailor their mobility gives a huge potential for diagnostic assays. An enzyme-linked immuno-sorbent assay (ELISA) with horseradish peroxidase (HRP) as label, proved the integrity, stability, and dispersibility of the antibody conjugates, LC-MS/MS provided evidence that a covalent link was established between these metal-organic frameworks and lysine residues in IgG antibodies.
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