Sixty females and 60 males between 10 and 15 years of age were interviewed about difficulties in current and past close same-sex friendships. Based on prior studies, it was hypothesized that females' closest same-sex friendships would be more fragile than those of males. Analyses comparing only the closest same-sex friendship of the two sexes demonstrated that females' current friendships were of a shorter duration, that females were more distressed than males when imagining the potential termination of their friendships, that more females' than males' friends already had done something to hurt the friendship, and that females had more former friendships that had ended than males had. Possible reasons are discussed for the greater vulnerability of this type of relationship for females.