Objective: The objective of this work was to carry out studies in the field of development of a hydroalcoholic extract from the liquorice root that has a high level of antimicrobial activity.Methods: For the antibacterial study of extracts, we have used the agar well diffusion method. In our research, we have utilized six test-strain microorganisms: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Proteus vulgaris ATCC 4636, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 885/653, and Bacillus subtilis ATCC 6633. Authors have applied vector theory for antimicrobial activity comparison of liquorice root extracts.Results: Phytochemical composition and antimicrobial activity of hydroalcoholic extracts from the liquorice root with the use of different concentrations of ethanol have been studied. The optimal range of ethanol concentration of 65±15% v/v has been found. The dependency between the integral index of antimicrobial activity of the extract and concentration of glycyram and licuroside has been found. The minimal concentration of glycyram and licuroside in the extract has been calculated for an exhibition of the target level of extract’s antimicrobial activity, which is 1.0 and 0.11% w/v, respectively.Conclusion: It has been found that the concentration of licuroside has greater influence on the integral index of extract’s antimicrobial activity in comparison with that one of glycyram. A highly effective technology for obtaining an extract with target phytochemical parameters has been suggested.
The use of block caving to mine ores and rocks of kimberlite deposits in Yakutia (Udachnaya, Yubileynaya Mir pipes) will ensure high economic efficiency and productivity, reduce damage to diamond crystals due to non-explosive technology of mining. At the same time, block caving creates high technological risks associated with the essence of the technique itself, as well as the mining, engineering and geological specifics of kimberlite deposits. To ensure the effectiveness of the block caving method and planned progression of block caving, it is necessary to assess the influence of technological risk factors at the stage when caving parameters are determined to reduce the consequences during the whole life cycle of the mine.
The relevance of this paper is conditioned by the study of the regulation of electronic money circulation in the countries of the world, in particular in Ukraine, the specifics of carrying out activities in the field of issuing electronic money and establishing the regulatory basis for such activities. The purpose of this study is to investigate and analyse the financial and legal regulation of electronic money circulation, and to establish the specifics of issuing electronic money. The following methods were used: dialectical method, formalisation, hermeneutical, legal, formal and legal, logical and legal methods, system, structural and functional method, axiomatic method, induction and deduction, analysis, synthesis, etc. The findings are the definition and establishment of the features of the concept of "electronic money" and "electronic money circulation"; the establishment of the regulatory framework for regulating electronic money; investigation of the history of the establishment of electronic money in the world; the regulations of the sphere of electronic money circulation in Ukraine are studied and ways to improve this sphere are proposed. Subjects who can engage in activities aimed at issuing electronic money were identified and the features of their activities were determined. The provisions set out in this paper are of practical value primarily for subjects whose activities are aimed at implementing electronic money circulation and regulating this activity, and for persons who somehow participate in electronic money circulation and whose rights may be violated by the providers of such services.
The high risk of technogenic accidents involving caving technologies due to the variability of the state of rock mass determines the parameters of variability taking into account geotechnical risks based on the knowledge of the rock mass obtained through continuous monitoring. The assessment of geotechnical risks in mining taking into account the increasing reliability of design data input obtained through mining exploration, additional research, and monitoring results can help promptly respond to possible dangers and their consequences. The suggested geotechnical risk assessment criterion helps determine the level of danger at every stage of block caving implementation and promptly develop actions to prevent these risks and reduce their dependency on the external and internal environment factors.
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