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In this study an antifungal protein from Urginea indica bulbs was purified to homogeneity by acid precipitation, Diol 300 Gelfiltration, and C 18 reverse phase HPLC. Its molecular mass was estimated to be 29 kDa and periodic acid-Schiff (PAS) staining showed that identified antifungal molecule is a glycoprotein. The neutralization of antifungal activity after periodate oxidation of 29 kDa glycoprotein suggests that the glycan part of the molecule appears to be involved in antifungal activity. N-terminal amino acid sequence of the purified protein was determined as SQLKAXIXDF. This sequence had no sequence similarity with any antifungal proteins. A polyclonal antiserum was raised against purified protein and used in immunolocalization analysis. Results suggest that it is localized to the cell wall of the bulb. Antifungal tests have demonstrated that U. indica protein exerts a fungistatic effect. It completely inhibits the germination of spores and hyphal growth of Fusarium oxysporum.

Among disparate infectious diseases viral infection in particular challenges survival of mankind across the globe. By superseding those events, 2019 novel (CoVID-19) or SARS-CoV-2 has become a new human health crisis threatening the world. Corona viruses (CoV) are large family of viruses that affects birds and mammals. In humans, Corona virus can cause respiratory tract infection ranging from the common cold to more serious infection such as SARS (Severe acute respiratory syndrome), MERS (Middle East Respiratory Syndrome) and CoVID-19 (Corona Virus Disease 2019) which can also become lethal. The Novel corona virus (CoVID-19) originated in 2019, is a novel virus which has not been identified in humans since past. At present, the source of CoVID-19 is not known. Although the infection is presumed to be in origin, person to person transmission is evident. Many supportive and symptomatic therapies where being carried out by the Medical practitioners as per the instructions of World Health Organization (WHO) with a hypothesis and there is no evidence that it works against CoVID-19. best to lower the current crises of infection is prevention and many measures that boosts the immunity are following by the people as directed by the Ministry of AYUSH.

The principle in this present research is to formulate Mesalamine containing colon targeted tablets by using different polymers and evaluate the effect of different polymers in drug release pattern. The matrix tablets of Mesalamine are formulated by polysaccharides based polymers like Cellulose acetate phthalate (CAP), Ethyl cellulose (EC), Guar gum (GG) and Xanthan gum (XG) which protects the drug to release in Stomach and Small Intestine. The invitro drug dissolution investigation of F2 (GG and XG) Matrix tablet was controlled by swelling into a viscous gel in colonic pH, which have been accomplished as the best tablet. The optimized tablet F2 was found to be stable in stability study (short term) with reproducible evaluation data, which also shows the highest swelling index, increased viscosity in colonic pH. The drug release pattern from the F2 formulation follows swelling and erosion behavior. From the data it show that F2 tablets suitable for providing colon targeted drug delivery.