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In recent years, several scientometrics and bibliometrics indicators were proposed to evaluate the scientific impact of individuals, institutions, colleges, universities and research teams. The h-index gives a breakthrough in the research community for assessing the scientific impact of an individual. It got a lot of attention due to its simplicity, and several other indicators were proposed to extend the properties of the h-index and to overcome its shortcomings. In this literature review, we have discussed the advantages and limitations of almost all scientometrics and bibliometrics indicators, which have been categorised into seven categories based on their properties: (1) complement of h-index, (2) based on total number of authors, (3) based on publication age, (4) combination of two indices, (5) based on excess citation count, (6) based on total publication count and (7) based on other variants. The primary objective of this article is to study all those indicators which have been proposed to evaluate the scientific impact of an individual researcher or a group of researchers.

The protein p53 has been extensively investigated since it was found 43 years ago and has become a "guardian of the genome" that regulates the division of cells by preventing the growth of cells and dividing them, that is, inhibits the development of tumors. Initial proof of protein existence by researchers in the mid-1970s was found by altering and regulating the SV40 big T antigen termed the A protein. Researchers demonstrated how viruses play a role in cancer by employing viruses' ability to create T-antigens complex with viral tumors, which was discovered in 1979 following a viral analysis and cancer analog research. Researchers later in the year 1989 explained that in Murine Friend, a virus-caused erythroleukemia, commonly found that p53 was inactivated to suggest that p53 could be a "tumor suppressor gene." The TP53 gene, encoding p53, is one of human cancer's most frequently altered genes. The proteinregulated biological functions of all p53s include cell cycles, apoptosis, senescence, metabolism of the DNA, angiogenesis, cell differentiation, and immunological response. We tried to unfold the history of the p53 protein, which was discovered long back in 1979, that is, 43 years of research on p53, and how p53's function has been developed through time in this article.

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