Background: Clostridioides Difficile is a well-known pathogen causing diarrhea of various degrees of severity through associated infectious colitis. However, there have been reports of infectious enteritis mainly in patients with ileostomy, causing dehydration through high-output volume; Case presentation: We report the case of a 46-year-old male patient, malnourished, who presented with high-output ileostomy following a recent hospitalization where he had suffered an ileo-colic resection with ileal and transverse colon double ostomy, for stricturing Crohn’s disease. Clostridioides Difficile toxin A was identified in the ileal output confirming the diagnosis of acute enteritis. Treatment with oral Vancomycin was initiated with rapid reduction of the ileostomy output volume; Conclusion: We report a case of Clostridioides Difficile enteral infection as a cause for high-output ileostomy, successfully treated with oral Vancomycin. We also review the existing literature data regarding this specific localized infection.
Testes of 12-day-old rats preincubated (90 min) and incubated (60 min) with FSH in Krebs-Ringer bicarbonate buffer (KRB) increased their uptake of [14C]methylaminoisobutyric acid and [14C]aminoisobutyric acid. The hormone was ineffective in sodium-free KRB. Transport of [14C]aminoisobutyric acid in the presence of methylaminoisobutyric acid (MeAIB; 30 mmol/l) was not stimulated by FSH, and uptake of [14C]cycloleucine was not increased by FSH in any of the experimental conditions used. It was concluded that in immature rat testes FSH affects only the sodium-dependent system which permits the transport of MeAIB (transport system A) and has no effect on the sodium-independent system which prefers leucine (system L) or the sodium-dependent system which does not transport MeAIB (system ASC).
Background and Objectives: Gut microbiota plays an important role in the wellbeing of the host through different interactions between microflora constituents. In certain instances, Clostridioides difficile may pullulate, causing infection with associated colitis that may vary in terms of severity from mild disease to severe colitis, with increased associated mortality due to its complications. However, there are few literature data regarding the association between Clostridioides difficile and ischemic colitis. Case report: We report the case of a 30-year-old male patient, overweight, with impending dehydration, who presented with hematochezia and colicky abdominal pain, with positive fecal tests for the detection of Clostridioides difficile infection and endoscopic appearance suggesting ischemic colitis in the sigmoid and left colon, confirmed by computed tomography and histology. The patient was treated with oral Vancomycin, with resolution of symptoms, and was reevaluated through colonoscopy eight weeks after discharge, with endoscopic mucosal normalization and histological scarring process on biopsy samples. Conclusion: We report one of the few cases in the literature of ischemic colitis associated with Clostridioides difficile infection, with resolution of clinical, endoscopic, and histologic changes after specific treatment with oral Vancomycin suggesting a possible association between the two diseases. We also review the existing literature data regarding this comorbid association.
Corrélations cliniques et pathologiques de l'hyperplasie des cellules neuro-endocrines chez les patients atteints de colite ulcéreuse Introduction. Plusieurs études ont montré que les cellules neuro-endocrines (CNE) sont accrues dans la muqueuse colorectale des patients atteints de colite ulcéreuse (CU) par rapport à la normale, principalement dans le côlon gauche. Un seuil de 3,2 NEC / crypte a été proposé par certains auteurs pour définir l'hyperplasie CNE chez ces patients. Cependant, les corrélations des changements de CNE avec les paramètres cliniques n'ont pas été décrites. L'objectif de cette étude était d'analyser les changements histologiques NEC, décrits par plusieurs décripteurs, chez les patients CU et d'identifier les corrélations clinico-pathologiques pertinentes. Matériel et méthodes. Nous avons analysé les biopsies coliques de 42 patients avec CU en mettant en évidence les cellules neuro-endocrines avec une coloration immunohistochimique à la Chromogranine A.
Systèmes de grading histologique chez les patients atteints de colite ulcéreuse: une perspective pratique de routine Introduction. La guérison histologique est devenue un objectif thérapeutique chez les patients atteints de colite ulcéreuse. Cependant, un consensus sur sa définition précise n'a pas encore été atteint. Un grand nombre de systèmes de grading histologique complexes pour la colite ulcéreuse sont disponibles dans la littérature, ce qui rend la standardisation compliquée. L'objectif de l'étude était d'identifier un système de grading histologique adapté à la pratique de routine et de contribuer ainsi à la standardisation du rapport histologique de l'activité inflammatoire dans la colite ulcéreuse. Matériaux et méthodes. Nous avons examiné rétrospectivement et noté 64 lames colorées H&E en utilisant l'index de Nancy (NI), le score Geboes (GS) et l'indice histopathologique Robarts (RHI) par trois pathologistes indépendants. Le niveau d'accord
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