Table of contentsP001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP effluxR. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. EllisP002 - Lower serum immunoglobulin G2 level does not predispose to severe flu.J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas, M. Briones, F. Rodríguez de Castro, C. Rodríguez GallegoP003 - Brain protective effects of intravenous immunoglobulin through inhibition of complement activation and apoptosis in a rat model of sepsisF. Esen, G. Orhun, P. Ergin Ozcan, E. Senturk, C. Ugur Yilmaz, N. Orhan, N. Arican, M. Kaya, M. Kucukerden, M. Giris, U. Akcan, S. Bilgic Gazioglu, E. TuzunP004 - Adenosine a1 receptor dysfunction is associated with leukopenia: A possible mechanism for sepsis-induced leukopeniaR. Riff, O. Naamani, A. DouvdevaniP005 - Analysis of neutrophil by hyper spectral imaging - A preliminary reportR. Takegawa, H. Yoshida, T. Hirose, N. Yamamoto, H. Hagiya, M. Ojima, Y. Akeda, O. Tasaki, K. Tomono, T. ShimazuP006 - Chemiluminescent intensity assessed by eaa predicts the incidence of postoperative infectious complications following gastrointestinal surgeryS. Ono, T. Kubo, S. Suda, T. Ueno, T. IkedaP007 - Serial change of c1 inhibitor in patients with sepsis – A prospective observational studyT. Hirose, H. Ogura, H. Takahashi, M. Ojima, J. Kang, Y. Nakamura, T. Kojima, T. ShimazuP008 - Comparison of bacteremia and sepsis on sepsis related biomarkersT. Ikeda, S. Suda, Y. Izutani, T. Ueno, S. OnoP009 - The changes of procalcitonin levels in critical patients with abdominal septic shock during blood purificationT. Taniguchi, M. OP010 - Validation of a new sensitive point of care device for rapid measurement of procalcitoninC. Dinter, J. Lotz, B. Eilers, C. Wissmann, R. LottP011 - Infection biomarkers in primary care patients with acute respiratory tract infections – Comparison of procalcitonin and C-reactive proteinM. M. Meili, P. S. SchuetzP012 - Do we need a lower procalcitonin cut off?H. Hawa, M. Sharshir, M. Aburageila, N. SalahuddinP013 - The predictive role of C-reactive protein and procalcitonin biomarkers in central nervous system infections with extensively drug resistant bacteriaV. Chantziara, S. Georgiou, A. Tsimogianni, P. Alexandropoulos, A. Vassi, F. Lagiou, M. Valta, G. Micha, E. Chinou, G. MichaloudisP014 - Changes in endotoxin activity assay and procalcitonin levels after direct hemoperfusion with polymyxin-b immobilized fiberA. Kodaira, T. Ikeda, S. Ono, T. Ueno, S. Suda, Y. Izutani, H. ImaizumiP015 - Diagnostic usefullness of combination biomarkers on ICU admissionM. V. De la Torre-Prados, A. Garcia-De la Torre, A. Enguix-Armada, A. Puerto-Morlan, V. Perez-Valero, A. Garcia-AlcantaraP016 - Platelet function analysis utilising the PFA-100 does not predict infection, bacteraemia, sepsis or outcome in critically ill patientsN. Bolton, J. Dudziak, S. Bonney, A. Tridente, P. NeeP017 - Extracellular histone H3 levels are in...

Safety culture and communication about surgical errors from the perspective of the health teamCultura de segurança e comunicação sobre erros cirúrgicos na perspectiva da equipe de saúde Cultura de la seguridad y comunicación sobre errores quirúrgicos en la perspectiva del equipo de salud ABSTRACT Objective: To analyze the safety culture related to the communication dimensions and event notification from the perception of the health team. Method: Survey carried out in a teaching hospital of Paraná through the application of the Survey on Patient Safety Culture questionnaire to 158 professionals working in surgical units from May to September 2017.The analysis of the data was done by descriptive and analytical statistics; dimensions with positive responses ≥75% represent strong areas for patient safety. Results: No dimension or item/question were considered strong to surgical patient safety. There was a difference, with a less negative perception from nursing in relation to medicine, in the dimensions "Return of the information and communication about the error" and "Frequency of events reports" (p<0.001). Conclusion:The health team perceives that there is fragility in the patient safety in relation to the communication dimension, demanding actions that promote the patient safety. RESUMOObjetivo: Analisar a cultura de segurança do paciente em relação às dimensões relativas à comunicação e notificação de eventos na percepção da equipe de saúde. Método: Survey realizado em hospital de ensino do Paraná mediante aplicação do questionário Hospital Survey on Patient Safety Culture a 158 profissionais atuantes em unidades cirúrgicas no período de maio a setembro de 2017. A análise dos dados se deu por estatística descritiva e analítica; dimensões com respostas positivas ≥75% representam áreas fortes para a segurança do paciente. Resultados: Nenhuma dimensão ou item/questão foram considerados fortes para a segurança do paciente cirúrgico. Houve diferença, com percepção menos negativa da enfermagem em relação à medicina, nas dimensões "Retorno da informação e comunicação sobre o erro" e "Frequência de relatos de eventos" (p<0,001). Conclusão: A equipe de saúde percebe fragilidade na segurança de pacientes em relação à dimensão comunicação, demandando ações promotoras da segurança do paciente. Palavras-chave: Cultura organizacional. Comunicação. Segurança do paciente. Centros cirúrgicos. RESUMENObjetivo: Analizar la cultura de la seguridad del paciente en relación a las dimensiones relativas a la comunicación y notificación de eventos en la percepción del equipo de salud. Método: Survey, realizado en un hospital de enseñanza del Paraná mediante el uso de la encuesta Hospital Survey on Patient SafetyCulture con 158 profesionales que actúan en unidades quirúrgicas durante el período de mayo a septiembre de 2017. Se realizó el análisis de datos a través de la estadística descriptiva y analítica. Las dimensiones con respuestas positivas ≥75% representan significativas áreas para la seguridad del paciente. Resultados: Ninguna dim...

Objective to analyze the in-hospital complications of prolonged hospital stay in patients with ischemic stroke or transient ischemic attack, admitted to the stroke unit of a tertiary hospital.Method this is an evaluative correlational study. All first-ever ischemic stroke or transient ischemic attack patients admitted were retrospectively analyzed. During hospital stay, the predictors of long-term hospitalization considered were: 1) clinical complications (pneumonia, urinary tract infection, pressure damage and deep vein thrombosis), and 2) neurological complications (malignant ischemic stroke and symptomatic hemorrhagic transformation).Results 353 patients were discharged in the study period. Mean age was 64.1±13.7 years old and 186 (52.6%) were men. The mean time of hospital stay was 13.7±14.3 days. Pneumonia (25.3±28.8 days, p<0.001), urinary tract infection (32.9±45.2 days, p<0.001) and malignant stroke (29.1±21.4 days, p<0.001) increased significantly the length of hospital stay compared to patients without any complications (11.2±7.1 days).Conclusion this study showed that three complications delayed hospital discharge in patients admitted in a stroke unit, two preventable ones: pneumonia and urinary tract infection. More intense measures to avoid them should be included in the performance indicators to reduce the length of hospital stay in stroke units.

Chagas disease remains a serious public health concern with unsatisfactory treatment outcomes due to strain-specific drug resistance and various side effects. To identify new therapeutic drugs against Trypanosoma cruzi, we evaluated both the in vitro and in vivo activity of the organometallic gold­(III) complex [Au­(III)­(Hdamp)­(L14)]Cl (L1 = SNS-donating thiosemicarbazone), henceforth denoted 4-Cl. Our results demonstrated that 4-Cl was more effective than benznidazole (Bz) in eliminating both the extracellular trypomastigote and intracellular amastigote forms of the parasite without cytotoxic effects on mammalian cells. In in vivo assays, 4-Cl in PBS solution loses the protonation and becomes the 4-neutral. 4-Neutral reduced parasitaemia and tissue parasitism in addition to protecting the liver and heart from tissue damage at 2.8 mg/kg/day. All these changes resulted in the survival of 100% of the mice treated with the gold complex during the acute phase. Analyzing the surviving animals of the acute infection, the parasite load after 150 days of infection was equivalent to those treated with the standard dose of Bz without demonstrating the hepatotoxicity of the latter. In addition, we identified a modulation of interferon gamma (IFN-γ) levels that may be targeting the disease’s positive outcome. To the best of our knowledge, this is the first gold organometallic study that shows promise in an in vivo experimental model against Chagas disease.

Reactions of p-toluenesulfohydrazide with R-isothiocyanates afford new ligands containing both the sulfonamide and thiosemicarbazide moieties (L R : R= cyclohexyl (Cy) or phenyl (Ph)). L R reacts with AgNO 3 in EtOH in a 2:1 M ratio leading to formation of colourless Ag(I) complexes of general formula [Ag(L R ) 2 ]NO 3 . The crystal structure of a representative complex was determined by crystallographic studies and shows the Ag(I) coordinated by two thiosemicarbazide ligands in a Smonodentate coordination mode along with a significant interaction with a nitrate counter-ion in a bent geometry.Photophysical studies show that both the free ligands and complexes are essentially non-luminescent at room temperature. At 77 K and glassy media, the silver complexes exhibit a luminescence band in the visible-light region. Besides, experimental and theoretical analyses suggest the population of the triplet state of these complexes after electronic excitation at around 250 nm. Overall, it was verified that the observed emission of the Ag(I) complexes can be attributed to 3 MLCT radiative decay and that the silver complex with L Ph shows a higher intensity emission than the complex with L Cy .