Leishmania (L.) chagasi is the etiological agent of visceral leishmaniasis, an important endemic zoonosis in the American continent, as well as in many other countries in Asia, Africa, and Mediterranean Europe. The treatment is difficult due to the high toxicity of the available drugs, high costs, and emergence of resistance in the parasites. Therefore, there is an urgent need for new leishmanicidal agents. The bisbenzylisoquinoline alkaloids have been related to antibacterial, antiprotozoal, and antifungal activities. The aim of this study was to evaluate the growth inhibitory activity of warifteine (bisbenzylisoquinoline alkaloid) against L. chagasi promastigotes in axenic cultures and the occurrence of drug-induced ultrastructural changes in the parasite. This bisbenzylisoquinoline alkaloid was isolated from the leaves and roots of Cissampelos sympodialis Eichl. (Menispermaceae), a plant commonly used for the treatment of various diseases in Brazilian folk medicine. Using the purified warifteine, the 50% inhibitory concentration (IC50) was determined at 0.08 mg/mL after 72 h in culture, inducing significant changes in the parasite morphology, like aberrant multisepted forms and blebs in the plasma membrane. In conclusion, warifteine represents an attractive candidate for future pharmacological studies aiming new leishmanicidal drugs.

This article aims to identify the prevalence of women who present risk for psychological distress in the pre-and postnatal period. A descriptive, exploratory study was conducted with a quantitative data approach, a study carried out at the pre and postnatal health outpatient

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Oral mucositis is a common and debilitating consequence of cancer patients undergoing antineoplastic treatment. There is no consensus on the most appropriate treatment for this condition. The best protocol to use should. consider each patient's specific needs and cost-effectiveness of treatment. Copaiba oil is a low-cost herbal medicine with scientifically proven anti-inflammatory, bactericidal, antitumor, and healing action.Abstract-Oral mucositis is a common and debilitating consequence of cancer patients undergoing antineoplastic treatment. There is no consensus on the most appropriate treatment for this condition. The best protocol to use should

Objective: Analyze the knowledge of home caregivers about health care related infections. Method:Descriptive and exploratory research, with qualitative approach, conducted with 75 caregivers of patient hospitalized at home. The data was collected through a semi-structured interview script, from August to September, 2016, processed on the IRAMUTEQ software and analyzed by the descending hierarchical classification.