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FORTE, A. L. S. A. Avaliação do potencial fotoquimioprotetor do extrato de Protium heptaphyllum da Amazônia em gel de aplicação tópica. 2012. 86 f. Dissertação (mestrado).

Curcumin has been traditionally used in food recipes for biological health benefits. However, these properties are compromised due to its very low bioavailability. Thus, this work assessed the impact of using natural potential bioenhancers to improve intestinal permeability and understanding the interaction of flavonoids with curcuminoids through molecular dynamic simulation. The intestinal permeability (P app) was measured on the human colon carcinoma cell line (Caco-2). The P app values measured on Caco-2 cell monolayers provided information regarding the increased permeability of curcumin across the intestinal barrier specially caused by the presence of citrus (100.45%), and milk thistle extracts (81.70%) at level +1 showed the higher P app increase (%) compared to level 0. With respect to the soft standardized green propolis EPP-AF extract, the P app increase was higher at level 0 (26.34%). Molecular dynamic (MD) simulations of curcumin with naringin and silybin B confirmed this increase of permeability of curcumin at higher concentrations through non-covalent interactions. These results suggest the prominent importance of the association of natural flavonoids as bioenhancers to increase curcumin bioavailability and health benefits.

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