Three female patients with Cantu syndrome were studied, two of whom were adults presenting with the complication of lymphoedema, as described earlier in a male patient with this syndrome. The aim of this study is to report the clinical characteristics of these three new cases and to emphasize that lymphoedema, as observed in two of the patients described here, has been observed in 11.5% of patients with Cantu syndrome and that heterochromia iridis, observed in one patient, is probably a new feature of this condition.

Objective: To evaluate the biochemical and nutritional status of smokers in treatment for smoking cessation and its association with anthropometric parameters. Methods: This is a cross-sectional study with convenience sample. Adult smokers were assessed at the start of treatment in the Interdisciplinary Center for Tobacco Research and Intervention of the University Hospital of the Federal University of Juiz de Fora (CIPIT/HU-UFJF). We evaluated the body mass index (BMI), conicity index (CI); waist circumference (WC), percentage of body fat (%BF), fasting glycemia, cortisol, insulin, total cholesterol (TC), LDL-c, HDL-c, triglycerides (TG) and metabolic syndrome (MS). Original article Rodrigues GRS et al. colesterol LDL-c, HDL-c, triglicéridos (TG) e síndrome metabólica (SM). resultados: A maioria dos participantes possuía SM e alto risco cardiovascular. A glicemia de jejum estava alterada em 30,4%. Houve correlação positiva significativa entre IMC e CC (r = 0,90; p = 0,0001), %GC (r = 0,79; p = 0,0001), IC (r = 0,65; p = 0,0001), glicemia (r = 0,42; p = 0,04) e TG (r = 0,47; p = 0,002). O IC também apresentou correlação positiva com insulina (r = 0,6; p = 0,001), glicemia (r = 0,55; p = 0,007), TG (r = 0,54; p = 0,008) e %GC (r = 0,43; p = 0,004). Pacientes com maior tempo de tabagismo tiveram maior risco de desenvolver SM (O = 9,6; p = 0,016). conclusão: Os fumantes avaliados tiveram maior risco de desenvolver SM, especialmente aqueles que fumavam por mais tempo, requerendo urgência para a cessação tabágica.cortisol 12,13 . In addition, chronic smokers are at increased risk for developing insulin resistance and inadequate compensatory response of insulin secretion, which promotes the association of smoking with an increased risk of type 2 diabetes mellitus 14 .Evaluation of endocrine-metabolic changes that promote tobacco use, can aid understanding of factors involved in the changes of body weight and the development of chronic diseases associated with smoking. This article aims to evaluate the biochemical and nutritional status of smokers at the start of treatment for smoking cessation and its association with anthropometric indices.

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