Asam gelugur fruits of Garcinia often used to reduce body weight. Lengkuas and kencur are traditional herbal that potential for antiobesity because they could reduce the level of phospholipids, triglycerides, and cholesterol. The aim of the research was to evaluate the potencies of these herbal as antiobesity by measurement of their water and ethanol extracts capabilities as in vitro inhibitor of pancreatic lipase activity. The water and ethanol extracts of asam gelugur fruits contained saponins and alkaliods, respectively. The water extract of lengkuas rhizomes contained alkaloids, flavonoids, saponins, and quinones, while the ethanol extract contained alkaloids, flavonoids, saponins, and steroids. The water extract of kencur rhizomes contained saponins and quinones, while the ethanol extract contained alkaloids, flavonoids, steroids, and quinones. The highest inhibitory effect of all extracts was obtained from the ethanol extract of asam gelugur fruits with value of 86.3% at 150 ppm. The highest inhibitory effect of lengkuas extracts was from the ethanol extract at 200 ppm (56.2%). The highest inhibitory effect of kencur was showed by the ethanol extract with the value 37.6% at 300 ppm. These values were higher than the inhibitory effect of the positive control (Xenical ® ) at 100 ppm (10.6%).Kata kunci: asam gelugur, lengkuas, kencur, inhibitory effect, antiobesity
Masyarakat biasanya menggunakan daun Sangketan untuk mengobati sawanan dengan mengusapkan daun sangketan, bawang, dlingo, dan bengkle yang sudah dihaluskan kemudian dioleskan pada ubun-ubun, kuping, leher, tangan, dan kaki. Daun sangketan mengandung alkaloid, flavonoid, saponin, steroid, dan terpenoid. Flavonoid telah terbukti mencegah atau memperlambat perkembangan beberapa kanker. Sebagian besar bertindak sebagai agen anti-oksidan dan anti-inflamasi. Tujuan dari penelitian ini adalah untuk mengetahui profil flavonoid dari ekstrak etanol daun sangketan (Achyrantes Aspera) secara kualitatif. Menggunakan metode eksperimen dengan pendekatan one shot case study. Serbuk simplisia di maserasi dengan etanol 96% selama 8 hari disertai pengadukan, filtrat diuapkan hingga menjadi ekstrak kental. Pengujian kadar flavonoid total ekstrak dilakukan dengan spektrofotometer, menggunakan larutan baku kuersetin. Hasil analisis dengan menggunakan spektrofotometri UV-Vis, konsentrasi ekstrak Sangketan 100 ppm lebih mendekati nilai absorbansi baku quersetin pada panjang gelombang 419,8 nm, dengan kadar flavonoid total 47,23%. Berdasarkan analisis dengan spektrofotometri UV-Vis pada panjang gelombang 419,8 nm, ekstrak etanol daun sangketan mengandung flavonoid total dengan kadar 47,23%. tanin.
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