Uji in Vitro Ekstrak Air Dan Etanol Dari Buah Asam Gelugur, Rimpang Lengkuas, Dan Kencur Sebagai Inhibitor Aktivitas Lipase Pankreas

Abstract

Asam gelugur fruits of Garcinia often used to reduce body weight. Lengkuas and kencur are traditional herbal that potential for antiobesity because they could reduce the level of phospholipids, triglycerides, and cholesterol. The aim of the research was to evaluate the potencies of these herbal as antiobesity by measurement of their water and ethanol extracts capabilities as in vitro inhibitor of pancreatic lipase activity. The water and ethanol extracts of asam gelugur fruits contained saponins and alkaliods, respectively. The water extract of lengkuas rhizomes contained alkaloids, flavonoids, saponins, and quinones, while the ethanol extract contained alkaloids, flavonoids, saponins, and steroids. The water extract of kencur rhizomes contained saponins and quinones, while the ethanol extract contained alkaloids, flavonoids, steroids, and quinones. The highest inhibitory effect of all extracts was obtained from the ethanol extract of asam gelugur fruits with value of 86.3% at 150 ppm. The highest inhibitory effect of lengkuas extracts was from the ethanol extract at 200 ppm (56.2%). The highest inhibitory effect of kencur was showed by the ethanol extract with the value 37.6% at 300 ppm. These values were higher than the inhibitory effect of the positive control (Xenical ® ) at 100 ppm (10.6%).Kata kunci: asam gelugur, lengkuas, kencur, inhibitory effect, antiobesity

Quorum Sensing Inhibition Activity of Water Extract of Rhizome Herbs onAeromonas hydrophila

“…Ginger, temu lawak, galangar, turmeric, kencur rhizome have been analyzed contained many substances such as Phenols, polyphenols, flavonoids, terpenoids, monoterpenes triterpennoids sesquiterpenes, glycosides, tannins, saponins, steroids, vitamin C, quinones or essential oils [7,8,9,10,11]. Several substances are polar substance which can be extracted with water.…”

“…Tanvir et al succeeded in getting polyphenols, flavonoids, tannins, and ascorbic acid content from turmeric water extract [9]. Iswantini et al obtained galangal and kencur water extracts containing alkaloids, saponins, flavonoids, and quinones [10].…”

“…Turmeric (Curcuma longa L.) contained high levels of polyphenols, flavonoids, tannins and vitamin C [9]. Galangal (Alpinia galanga L.) contains alkaloids, saponins, flavonoids, triterpenoids, and quinones [10]. Kencur (Kaempferia galanga L.) contained alkaloids, flavonoids, polyphenols, tannins, monoterpenes, sesquiterpenes, steroids [11].…”

Fat-Rich Food Review on Obesity Control through Induction Enzyme Inhibitors

“…Orlistat is a derivative of hydrogenated lipstatin and pancreatic lipase inhibitor isolated from Streptomyces toxytricini bacteria (Ballinger & Peikin, 2002). Based on literature studies, the effective concentration of orlistat used as a lipase inhibitor is 100 ppm, where the inhibitory ability is 10.6% (Iswantini et al, 2010).…”

Evaluation of Indonesian Anti-obesity Traditional Medicinal Plants: A Systematic Review and Meta-analysis on Pancreatic Lipase Inhibition Activity

“…Indonesian indigenous herbal plants vary greatly, and among them, 76 of the plants are evidenced to exert anti-obesity properties [11]. Previous researches reported performance of anti-obesity treatments using some herbal plants such as jati belanda (Guazuma ulmifolia), kemuning (Murraya paniculata) leaves, kelembak (Rheum officinale) roots, tempuyung (Sonchus arvensis) leaves [12,13]; sirih merah (Piper crocatum) [14]; asam gelugur (Garcinia atroviridis), kunci pepet, (Kaempferia rotunda), lengkuas (Alpinia galanga), daun asam Jawa (Tamarindus indica leaves), kencur (Kaempferia galanga) [15,16]; and teh hitam (Camelia sinensis) [17].…”