Lucio’s phenomenon is an uncommon reaction characterized by severe necrotizing
cutaneous lesions that occurs in patients with Lucio’s leprosy and lepromatous
leprosy. It is considered by some authors as a variant of type 2 or 3 reaction.
Death can occur because of blood dyscrasia or sepsis. Precipitating factors
include infections, drugs and pregnancy. We report a 31-year-old female patient
exhibiting both clinical and histopathological features of lepromatous leprosy
and Lucio’s phenomenon presenting favorable response to treatment. We complement
our report with a literature review of the Brazilian cases of Lucio’s phenomenon
published in Portuguese and English.
Diffuse cutaneous melanosis is a rare complication of metastatic melanoma related
to a worse prognosis. There are few cases reported in the literature. Its
pathogenesis has not been completely elucidated, although studies have suggested
certain mechanisms for its occurrence. It is clinically manifested as a
blue-gray discoloration of the skin and mucous membranes in a cephalo caudal
progression and usually associated with melanuria. Skin and mucosa
histopathology reveals only the presence of melanophages in the dermis, mainly
perivascular, and free interstitial melanin. We report the case of a 68-year-old
male with metastatic melanoma, diffuse hyperpigmentation of the skin and
melanuria.
Angiosarcoma is a rare and aggressive tumor with high rates of metastasis and
relapse. It shows a particular predilection for the skin and superficial soft
tissues. We report three distinct and typical cases of angiosarcoma that were
diagnosed in a single dermatology clinic over the course of less than a year: i)
Angiosarcoma in lower limb affected by chronic lymphedema, featuring
Stewart-Treves syndrome; ii) a case of the most common type of angiosarcoma
loated in the scalp and face of elderly man and; iii) a skin Angiosarcoma in
previously irradiated breast. All lesions presented characteristic
histopathological findings: irregular vascular proliferation that dissects the
collagen bundles with atypical endothelial nuclei projection toward the
lumen.
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