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Aims This case report describes an orthodontic and aesthetic rehabilitation in a patient with Turner syndrome. Methods and results Careful anamnesis was performed to find the patient's medical history. Based on dental casts, radiographies and photographies it was observed alterations in the craniofacial complex, in the occlusion and in the dental morphology. For the orthodontic treatment, rapid maxillary expansion was performed, followed by the use of fixed orthodontic appliance. At the end, aesthetic rehabilitation, with direct composite resin veneers, was utilized for the correction of existing diastema. Treatment goals were achieved by observing an improvement in facial and smile harmony. Conclusion The orthodontic treatment followed by aesthetic rehabilitation of dental morphology showed to be feasible in a patient with Turner syndrome based on an early diagnosis and craniofacial growth follow‐up.

Objectives The aim of this systematic review and meta-analysis was to assess the effects of low-level laser therapy (LLLT) on the orthodontic mini-implants (OMI) stability. Materials and methods An unrestricted electronic database search in PubMed, Science Direct, Embase, Scopus, Web of Science, Cochrane Library, LILACS, Google Scholar, and ClinicalTrials.gov and a hand search were performed up to December 2020. Randomized clinical trials (RCTs) or non-randomized clinical trials (Non-RCTs) that assessed the effects of LLLT on the OMI stability were included. Data regarding the general information, LLLT characteristics, and outcomes were extracted. The authors performed risk of bias assessment with Cochrane Collaboration’s or ROBINS-I tool. Meta-analysis was also conducted. Results Five RCTs and one Non-RCT were included and 108 patients were evaluated. The LLLT characteristics presented different wavelength, power, energy density, irradiation time, and protocol duration. Five RCTs had a low risk of selection bias. Two RCTs had a low risk of performance and detection bias. All RCTs had a low risk of attrition bias, reporting bias and other bias. The Non-RCT presented a low risk of bias for all criteria, except for the bias in selection of participants. The meta-analysis revealed that LLLT significantly increased the OMI stability (p < 0.001, Cohen’s d = 0.67) and the highest clinical benefit was showed after 1 (p < 0.001, Cohen’s d = 0.75), 2 (p < 0.001, Cohen’s d = 1.21), and 3 (p < 0.001, Cohen’s d = 1.51) months of OMI placement. Conclusions LLLT shows positive effects on the OMI stability.

This study aimed to conduct a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of the btulinum toxin-A (BT-A) in patiets with mood disorders. PubMed, Scopus, Web of Science, Cochrane Library and LILACS were searched without restrictions up to July 2022. The PICOS strategy was used for the selection of studies and risk-of-bias assessment was performed using Cochrane's tool for RCTs. RCTs were included if they compared BT-A treatment on facial muscles in patients with mood disorders to placebo. After assessment of the full texts, seven studies were selected. Five studies had low risk of bias for the generation of random sequence and blinding of participants and professional domains. A total of four studies showed a low risk of bias for the allocation concealment and blinding of the evaluation of the domain results. The domain of selective reports showed a low risk of bias in all included studies. However, four studies presented a high risk of bias for the domain of other biases. The meta-analysis was based on the mean difference or standardized mean difference between the BT-A and placebo groups for each selected trial and revealed that the BT-A group showed a significant improvement in the symptoms of depression when compared to placebo. This study revealed that the BT-A application into mimic muscles of the upper third of the face improves the mood disorders, but it was not possible to guarantee whether the aesthetic benefits can contribute to reducing the severity of the depressive state.

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Poly-L-lactic acid (PLLA) is a synthetic, biocompatible and biodegradable polymer of the alpha-hydroxy acid family. This substance has provided satisfactory and safe results in several medical applications in the last three decades. The brand name Sculptra® has been widely investigated in the area of facial cosmetics. The aim of this study was to performed a systematic review of the effects of Sculptra® for facial rejuvenation. This review was registered on the prospero platform under protocol CRD42021277434. A careful search was conducted in the Pubmed, Scopus, BVS, Scielo, Web of Science, LILACS and Cochrane Library databases up to February 2021. Gray literature was consulted at Open Grey. In addition, a manual search was performed. Clinical studies were selected, without restriction of publication date or language. Data synthesis and risk of bias assessment of the included studies was performed by two independent authors. Eight clinical studies were selected for data synthesis (three randomized clinical trials, two prospective cohorts and three retrospective cohorts). Data synthesis demonstrated that Sculptra® is considered an effective, safe and long-acting agent for collagen volumization and biostimulation. The assessment of the risk of bias of the RCTs revealed a low risk of bias in all domains, with the exception of the domain of concealment of allocation of participants. Within the limitations of the systematic review, the use of Sculptra® for facial rejuvenation is effective, safe and long-lasting.