Introduction: Externalizing disorders are more prevalent in rural than urban settings and account for disproportionately high mental health service costs for rural adolescents. Although cultural stressors such as discrimination have been associated with externalizing problems in ethnic minority youth broadly, this relationship is understudied in Latinos, particularly those in rural settings. Further, though the associations of family processes such as familism and family conflict have been studied in relation to youth externalizing symptoms, whether these processes change in the face of adolescent discrimination stress remains unknown. Methods: A moderated multiple mediation model was used to examine the association between perceived discrimination, externalizing symptoms, and the indirect effect of family factors (familism, and family conflict) in a large sample (n = 455) of rural Latino youth. We also evaluated whether indirect and direct effects of discrimination on externalizing symptoms differed in boys versus girls. Results: Familism and family conflict each independently mediated the relationship between discrimination related stress and externalizing symptoms. However, discrimination had a direct effect on externalizing symptoms for boys only. In girls, this association held only when family factors were accounted for. Post-hoc analyses reveal that the moderating effect of sex on discrimination is driven by differences in rule-breaking behavior, as opposed to aggressive behavior. Conclusion: Findings suggest that discrimination is associated with changes in the family environment which in turn invoke elevated risk for externalizing problems. Further, family-focused interventions that address externalizing problems may be especially effective for adolescent girls.Characterized by emotion dysregulation and impulsivity, externalizing disorders include maladaptive behaviors directed toward other people and their property (American Psychiatric Association, 2013), and are most often associated with mental health referrals in childhood and adolescence (Kazdin, 1991). Externalizing disorders are associated with poor academic performance (Nelson, Benner, Lane, & Smith, 2004), peer and parental rejection, and delinquency during adolescence (Barnow, Lucht, & Freyberger, 2005), as well as substance use and criminal activity in adulthood (Farrington, 1989). The National Comorbidity Survey Replication-Adolescent supplement estimates the prevalence of externalizing disorders in adolescents is 19.6% (Merikangas et al., 2010), and that the presence of externalizing disorders in young adulthood is correlated with being male, Latino and from a rural community (Forster,