Vitamin D deficiency was found to have higher prevalence in poorly controlled diabetic patients. Also, vitamin D deficiency was found to have higher prevalence in diabetic micro vascular complications. On the other hand, patients with CKD in different stages suffer from vitamin D deficiency. Our study was conducted on100 diabetic patients (50 diabetic patients without nephropathy and 50 diabetic patients with nephropathy) in addition to 50 healthy subjects as a control group; to evaluate level of vitamin D in both control group, diabetic patients without nephropathy and diabetic patients with nephropathy throughout different stages of chronic kidney disease (CKD).This study revealed that there was a significant difference in the level of vitamin D between control group and diabetic patients group. It tended to be lower in diabetic patients; also, there was highly significant difference between diabetic patients without nephropathy and diabetic patients with nephropathy. Vitamin D level was lower in diabetic patients with nephropathy group; also, there was significant difference between different stages of CKD in diabetic patients with nephropathy group. Level of vitamin D showed a progressive decline throughout different stages of CKD, it was the least in stage 3 CKD. In diabetic patients with nephropathy there were negative correlations between serum creatinine and albumin/creatinine ratio with vitamin D while there was positive correlation between serum albumin and eGFR with vitamin D.
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