Oxytetracycline is an antibacterial agent used widely for therapy of systemic bacterial infections in farmed fish, Thailand. The pharmacokinetics of oxytetracycline after intrasinus and oral administration in giant tiger prawn was examined by using a rapid high-performance liquid chromatography (HPLC) method. The kinetics of oxytetracycline was described by a two-compartment model after intrasinus administration. The distribution half-life ( T 1/2 a = 0.089 h) of oxytetracycline was shorter than the elimination half-life ( T 1/2 b = 23.1 h). The kinetics of orally given oxytetracycline was fitted to a one-compartment model. The bioavailability was calculated to be 59.9%. The time required for drug absorption (TDA), defined as the time for absorption to reach 90% of the maximum level, was approximately 9 h. An apparent steady-state distribution (Vss: 0.41 L/kg) was found for oxytetracycline in the present study, which is smaller than in fish species.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.