2-Alkylamino-4,6-diphenylpyrimidines are acylated only at nitrogen after treatment with lithium di-isopropylamide (LDA). 4,6-Diaryl-1 -benzylpyrimidin-2(1 H)-ones can be acylated and alkylated at the a-CH, group. 1 -Methyl-4,6-di-p-tolylpyrimidin-2(1 H) -one forms a carbanion which undergoes dimerisation.
Avermectin BIa Aglycon (8) and Monosaccharide (7). A mixture of 46.2 mL of H20,46.2 mL of concentrated H2S04, and 170 mL of THF was added over 30 min to a solution of 3 (22.2 g, 0.025 mol) in 200 mL of THF stirred in an ice bath. After the addition was completed, the reaction mixture was left at 18 °C for 24 h under a nitrogen atmosphere. Analysis by TLC and HPLC showed after 2 h about 60% of 3 and 40% of 7 and after 16 h about 60% of 7 and 40% of 8. It also showed that the product
S.ummary Primary alkyl and benzyl amines are converted by 2,4,6-triphenylpyrylium fluoride into the corresponding pyridinium fluorides which thermolyse smoothly a t 100--.130 "C to give alkyl and benzyl fluorides, the latter in yields of 60-7004, the former in somewhat lower yields.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.