Metallation studies with pyrimidines

Abstract

2-Alkylamino-4,6-diphenylpyrimidines are acylated only at nitrogen after treatment with lithium di-isopropylamide (LDA). 4,6-Diaryl-1 -benzylpyrimidin-2(1 H)-ones can be acylated and alkylated at the a-CH, group. 1 -Methyl-4,6-di-p-tolylpyrimidin-2(1 H) -one forms a carbanion which undergoes dimerisation.

Molecular structure, vibrational, UV and NBO analysis of 4-chloro-7-nitrobenzofurazan by DFT calculations

“…The strong characteristic absorptions due to the C-X stretching vibrations are to be observed [43][44][45][46], with the position of the band being influenced by neighbouring atoms or groups-the smaller the halide atom, the greater the influence of the neighbour. Bands of weak to medium intensity are also observed due to overtones of the C-X stretching vibrations.…”

Uracil–4‐Hydroxyuracil tautomerism revisited

“…The tautomerism displayed by the uracil-4hydroxyuracil system [scheme (l)] is of interest because it is one of the simplest examples of nucleic acid-base taut0merism.l The interest in this system was initially spurred by a proposed relationship between the nucleic acid-base rare-tautomeric forms and point mutations occurring during replications.2 For the tautomeric equilibrium shown in (l), the equilibrium constant Kt has been reported to lie in the range 10-3 to (refs. [2][3][4] in neutral aqueous solution, strongly favoring the diketo form. I t has recently been suggested5 that by analogy with the 2-pyridone6 system, the hydroxy form of uracil may become more favored in a nonpolar environment even though available vapor phase studies7 do not reveal the presence of hydroxyuracils.…”

N-Butyl-4,6-diphenylpyrimidin-2-amine

“…For biological applications of pyrimidine derivatives, see: Katrizky et al (1982); Brown & Lyall (1964). For the synthesis, see: Goswami et al (2009).…”

“…Substituted pyrimidine derivatives are utilized as antiviral and antifungal agents (Katrizky et al, 1982;Brown & Lyall, 1964). 2-Butylamino-4,6-diphenyl pyrimidine has been synthesized by solid-phase microwave irradiation (Goswami et al, 2009).…”