Diabetes mellitus (DM) has been defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. This study includes (84) subjects, their age ranged from (40 to 54) years. (20) subjects were healthy chosen as control group and (64) patients with type 2 diabetes mellitus were divided into three groups according to their type of anti diabetic therapy: (23) newly diagnosed group without therapy (Group1), (20) with metformin therapy (Group2) and (21) with metformin plus glibenclamide therapies (Group3). In the study lipid profile level were quantitatively determine by enzymatic methods, in addition to that fasting plasma glucose (FPG), Glycated hemoglobin (HbA1c%) and body mass index (BMI) were identified in the patients. There is significant increase in the level of lipid profile in patients group. Metformin alone produce a non-significant favorable effect on all lipids profile parameters while metformin plus glibenclamide showed a significant reduction in TC and LDL-C.

The oxidative stress is one of the main cause for cardiovascular diseases (like Hypertension) also one of the results of these diseases. This study involved 56 subjects matched ages and sex divided into two groups; 28 hypertensive subject and 28 healthy subject as control group. The following analysis was done: 4-Hydroxy-2-nonenal(4HNE) and albumin. The resultsshow that there is a significant increase in (4HNE) between patients group and control group. The increase in 4HNE which is a product of lipid peroxidation is attributed to destruction in body cell caused by due to the increase in stress events. It has been concluded that is important nappy on ideal weight, because obesity considered main factors for heart disease and hardening of the arteries. The aim of this study was to investigate the relationship between of some oxidative stress markers and cardiovascular diseases.

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Triglycerides and lipoproteins are threat features for Cardio Heart Disease. The word "nano" is derived from the Greek word "nanos" which means slight and it is used as introduce for one billionth part (10-9). Conferring to American Society for Testing and Materials. Nanoparticles are those atoms which have two or more than two dimensions and are in the magnitude range of 1-100 nm. lipid profile was measured by enzymatic method with using diagnostic kit from (BioMareuix, France). Gold nanoparticles were synthesized by chemical reduction, typically performed by reducing HAuCl4 in aqueous solutions using inorganic reducing agent. The results revealed a significant impact of gold nanoparticles on total cholesterol, LDL, HDL, triglycerides and VLDL. The gold nanoparticles have cardio-protective and cardio-risk impact. Because it can increase the level of good cholesterol (HDL) and bad cholesterol (LDL).