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Background: Schizophrenia is a heterogeneous disease, which includes psychotic features, cognitive impairment and daily performance disruption. Aim: To explore the association between quality of life and locus of control in schizophrenic patients. Subjects and method: Design: A descriptive correlational research design was utilized for the current study. Setting:The study was conducted in psychiatric outpatient clinics at Port Said Psychiatric Health Hospital. Tool: Tool I: Schizophrenia Quality of Life Scale; composed of 30 items.Tool II: General Locus of Control Scale which is composed of 24 items, in addition the personal and clinical data sheet. Results: Revealed that there was a significant association between total quality of life and presence of antipsychotic side effects & duration of hospitalization. Locus of control was found to be significantly associated with working status and education level. There was positive statistically significant correlation between quality of life and locus of control. Conclusion: Most of the studied patients showed the high quality of life and external locus of control, there was a positive statistically significant correlation between the quality of life and locus of control. Recommendations: Developing educational strategies regarding the locus of control to encourage patients to attribute their ill health to the events under their control rather than to ‗chance.'