COVID-19 [coronavirus disease 2019] has resulted in over 204,644,849 confirmed cases and over 4,323,139 deaths throughout the world as of 12 August 2021, a total of 4,428,168,759 vaccine doses have been administered. The lack of potentially effective drugs against the virus is making the situation worse and dangerous. Numerous forces are working on finding an effective treatment against the virus but it is believed that a de novo drug would take several months even if huge financial support is provided. The only solution left with is drug repurposing that would not only provide effective therapy with the already used clinical drugs, but also save time and cost of the de novo drug discovery. The initiation of the COVID-19 infection starts with the attachment of spike glycoprotein of SARS-CoV-2 to the host receptor. Hence, the inhibition of the binding of the virus to the host membrane and the entry of the viral particle into the host cell are one of the main therapeutic targets. This paper not only summarizes the structure and the mechanism of spike protein, but the main focus is on the potential covalent spike protein inhibitors.
<p>A coronavirus identified as 2019 novel coronavirus (COVID-19) is the etiological agent responsible for the 2019-2020 viral pneumonia outbreak that commenced in Wuhan has been declared as a pandemic by the World Health Organization. The virus is predominantly spread from person-to-person mainly through airborne, fomite, contact, and droplet from the infected patients. Also, the lack of definitive treatment is another concern that needs consideration. The novel 2019 SARS-CoV-2 enters the host cell by binding of the viral surface spike glycoprotein (S-protein) to angiotensin-converting enzyme 2 (ACE2). Mpro is a key coronavirus enzyme, which plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for this virus. Considering the importance of these two proteins in the viral infection, these were preferred as a potential drug target against Covid19. In this study, we screened potential antiviral drugs from the Pubchem database and natural antiviral agent quercetin for induced fit docking against these two key proteins. The identified top hit was further evaluated through molecular dynamic simulations. Our results suggest that the antiviral drugs Indinavir and Famciclovir could be a potential drug against Covid19. <br></p>
Dementia word represents sequence of medical problems which causes damage the brain and gradually it develops time to time. As Stated By medical research, its more than 200 subtypes and provokes to dementia with Alzheimer’s disease (AD) which occurs in most of the old age people.AD is unchangeable growing autoimmune problem which affects Daily life cognitive process activities like thinking skills are disrupted In Advanced progressive stage thought process falls down and easy task makes them critical and unworkable. AD Patients and families life quality transfers drastically and it effects very bad on caretakers bodied &psychiatric conditions. This survey explains the writings of research in order to disclose the advantage of appealing non-developmental interference like canonic music therapy to upgrade the AD Patients life of the quality. The report purpose is to focus on the footprint of this AD on the caretakers life.AD patients finding better by Symphonic music therapy which showing sound results in the treatment and improved acculturation and the keeping there dignity & reputation of the life.
The pandemic COVID-19 is generating worldwide disruption, straining health systems, causing morbidity and death, and placing people with ADRD in danger. In this article, we look at the present and anticipated implication son people with ADRD as a result of the epidemic. We examine and offer reducing measures and death in peopleCOVID-19’s effect on ADRD diagnosis and medical care in people with ADRD; and the COVID-19 repercussions of societal reactions in various ADRD care settings. COVID-19’s influence on physicians and caregivers of people with ADRD; stigma, mental health, and trauma during COVID19; and the prospective COVID-19 impact research on ADRD. Despite much uncertainty, we may be able to avoid or lessen the suffering caused by the epidemic of COVID-19implications for persons with ADRD and about their careers. Anticipated the potential patterns of COVID-19 effects in the world dependent on data gathered from Kaggle and used the Optum Labs Data Warehouse (OLDW),
Aim:The Object of this research is to exhibit the potency and advantage of music therapy for Keepers and Alzheimer’s disease (AD) people. Methods: From 2020 to 2021, a research group scrutinized and investigated 32 persons with Alzheimer’s Disease (ICD-10) medicated by general practitioners, music psychotherapists and neurologists through MMSE. The musical brain analysis with medical results of the patients was estimated and also the response of the tutors and the Patients of Alzheimer’s were Noted. In Family or Personal Sessions, musical instruments were added. The MMSE was used for the patient’s Evaluation Purpose. Under Neurologist’s Supervision, the examination was re-conducted every six months. Finally, 31 patients withAlzheimer’s Medication were Observed And calculated.
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