Hyperlipidemia, hyperlipoproteinemia or dyslipidemia is the presence of elevated or abnormal levels of lipids and / or lipoproteins in the blood. Lipid and lipoprotein abnormalities are extremely common in the general population and are regarded as a highly modifiable risk factor for cardiovascular disease due to the influence of cholesterol, one of the most clinically relevant lipid substances in atheroscterosis.
Aim of the work:This study aimed to evaluate the possible treatment and protective effect of triphala on hyperlipidemic rats.
Material and methods:Six groups (5rat/group) of female albino rats (Rattus albinus) were used. The 1st group used as control, in the 2 nd group hyperlipidemia (25% fat & 2% cholesterol) was induced for 3 weeks only then sacrified , the 3 rd group was hyperlipidemic rats for 3 weeks then left for other 3 weeks without any additional treatment as a recovery period, the 4 th group served as hyperlipidemic group for 3 weeks then treated with triphala for another 3 weeks (25 mg/100 gm b. wt.), the 5 th group was hyperlipidemic (25% fat & 2% cholesterol) for 6 weeks and the 6 th group served as hyperlipidemic rats for 6 weeks, and at the same time given triphala (25 mg/100 gm b. wt.) by oral administration.
Results:The biochemical parameters showed highly significant increase in the body weight, serum glucose, ASAT, ALAT, GGT, LDH, total protein, albumin and total lipids in liver .Many histopathological and histochemical changes were detected in liver tissue of the hyperlipidemic rats. Meanwhile, the treatment with triphala ameliorated the biochemical parameters, histological and histochemical results.
Conclusion:It is recommended to use triphala in diets for hyperlipidemic patients or those people who have hyperlipidemic family history.
Background: Hyperlipidemia, hyperlipoproteinemia, or dyslipidemia means the presence of elevated or abnormal levels of lipids and/or lipoproteins in the blood. Hyperlipoproteinemia happens when there are large amounts of lipids (fats) in the bloodstream. These lipids include triglycerides, phospholipids, cholesterol, and cholesterol esters. Aim of the work: this study aimed to evaluate the possible protective effect of Aphanizomenon flos-aquae (AFA) as a natural hypolipidemic product on body weight, hematological parameters, and FBG of adult male albino rats, in comparison with Slimquick (Orlistat 120 mg) as a synthetic hypolipidemic drug and their ability to treat hyperlipidemia or to prevent it. Material and methods: fifty-six male albino rats (Rattus albinus) were used and categorized into eight groups (7rats/group). The 1st group (C) rats were used as a control, the 2nd group (HFD) rats were treated with high fat diet (HFD) (2% cholesterol) to induce hyperlipidemia for 4 weeks only then scarified, the 3rd group (A) rats were orally administrated with AFA only for 4 weeks(94.5 mg/kg body weight /day), the 4th group (H+A1) rats were treated with HFD enriched with 2% cholesterol for 2 weeks to induce hyperlipidemia and the other 2 weeks were fed on the same HFD plus AFA extract administration, the 5th group (H+A2) rats were treated with HFD diet enriched with 2% cholesterol for 4 weeks to induce hyperlipidemia and then they were fed on normal basal diet (BD) plus AFA extract administration for another 2 weeks, the 6th group (S) rats were orally administrated with Slimquick only for 4 weeks (5 mg orlistat / rat/day), the 7th group (HFD+S1) rats were treated with HFD diet enriched with 2% cholesterol for 2 weeks to induce hyperlipidemia and the other 2 weeks rats were fed on the same HFD plus Slimquick extract administration, the 8th group (HFD+S2) rats were treated with HFD diet enriched with 2% cholesterol for 4 weeks to induce hyperlipidemia and then they were fed on normal basal diet (BD) plus Slimquick extract administration for another 2 weeks. Results: Body weight, hematological parameters, and FBG changes were shown in the blood serum of rats, these changes included a very highly significant increase in the mean value of body weight gain, White blood cells count (W.B.C.s), and fasting blood glucose (FBS)in high-fat diet (HFD) group. In contrast, a significant decrease in Red blood cell count
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