Purpose: To stress the influence of Coenzyme Q10 (CoQ10) on the structural properties of liposomes as model membranes and to investigate the possible role of CoQ10 or CoQ10 doped in liposomes when topically instilled as eye drops, in preventing cataract.Methods: The molecular interaction between liposomes and Coenzyme Q10 was examined using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). Rat pups were randomly divided into six groups comprising 15 pups. Group (1), control group. Group (2), untreated model of cataract, received a single subcutaneous injection of sodium selenite. Instillation of pure CoQ10 (Group 3), CoQ10 encapsulated into neutral (Group 4), positive (Group 5) and negative (Group 6) Dipalmitoyl phosphatidylcholine (DPPC) liposomes on the opacification of lenses in rat pups after sodium selenite injection was topically received.Results: The incorporated CoQ10 is probably associated with lipid bilayers where it interacts to a large extent and perturbs them. This results in strong broadening and shift to lower temperature (94°C) of the major characteristic endothermic peak of pure DPPC at 105°C. FTIR showed that the incorporation of CoQ10 into DPPC induces a conformational change in the polar region of DPPC. Ophthalmological and Biochemical studies revealed that CoQ10 alone followed by negatively charged liposomes doped with CoQ10 are more effective in reducing the progress of cataract as well as improving the lens soluble proteins levels and total antioxidant capacity.Conclusion: The interactions of CoQ10 with membrane systems may contribute to a better understanding of CoQ10 physiological properties and the development of therapeutically advanced systems.
Using the methods of classical statistical mechanics, the field dependence of magnetization curves is calculated at room temperature for SmCo 5 , PrCo 5 and YCo 5. In addition, we discuss the dependence of the magnetization vector on the direction of the magnetic field, along and perpendicular to the easy-axis. We correlate the orientation of the magnetization vector, relative to a specific crystallographic axis, to the angular coordinates of the most probable location in a probability landscape of these anisotropic magnetic systems.
Polymer gel dosimeter have been developed as means of detecting and verifying an absorbed doses given to cancer patients for radiotherapy in the range (0-10Gy) as measured and verification dose distributions of three-dimensional (3D) treatments. This article reports on the dosimeter of a new N-isopropanol acrylamide NIPAM, high weight percent T%, %C the mass percent of all comonomer polymer gel formulation (6T%, 20C%), optimized for magnetic resonance imaging (MRI). The aim to investigated MR-based polymer gel dosimeter as a three-dimensional 3D dosimeter in IMRT. Magnetic resonance spin-spin relaxation rate images were acquired and, after calibration, converted to absorbed dose distribution. The dose maps were compared with the dose distribution calculated using ion chamber in one plan and radiographic film for two plans. The dosimeters were irradiated by 4, and 10MV photons for doses in the range (4-10) Gy. The multiecho sequence was used for the evaluation of T 2 (spin-spin relaxation times) in the irradiated gel dosimeters. (%dd) percentage depth dose for (IMRT) intensity modulated radiation therapy / polymer gel & Magnetic resonance imaging = 5.7% at 5cm, other the average dose are 10.45 for dose profile, where %dd percentage depth dose for (IMRT) intensity modulated radiation therapy /ionization chamber and radiographic film(IC&RF) = 4.6% at 5cm other the average dose are 10.45 for dose profile. DVH dose volume histogram for polymer gel & magnetic resonance imaging = 94%, but DVH dose volume histogram for point by point ionization chamber and radiographic film = 86%.which lessince timing for protocol of integral part of verification radiation therapy.
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