Introduction:In endeavor to suppress the cervical carcinoma there are several possible approaches including measures of primary and secondary prevention. So far effects of these measures on the number of cases and mortality rate of cervical carcinoma were modest. Only exception is organized testing based on cytological exam of the cervical smear – Pap test, which has proven to be highly effective in reducing the number of cases and mortality of cervical carcinoma in countries with this program.Goal:of this research is analysis of correlation between abnormal cytological test results and pathohistological diagnosis of all patients in the analyzed period. ]Material and methods:Research is descriptive, analytical, comparative, and partly epidemiological. Results of cytological and pathohistological diagnostic in the period between January 1, 2009 and December 31, 2011 were used for analysis. All analyzed patients had colposcopy exam and Pap test, and patients with abnormal results of this test underwent cervical biopsy for pathohistological diagnostics.Results:We came to following results and conclusions: total number of L-SIL and H-SIL (PAPA III) results was 395 (6.20%) in comparison to total sample of 5894 (92.44%) patients. There is a statistically significant difference in relation to PHD result of cervical biopsy after L-SIL and H-SIL (PAPA II and IV), and highest statistical margin is in relation of CIN II changes to cytological findings, issued at Clinic of Obstetrics and Gynecology and other health institutions. We come to conclusion that the highest percentage of patients with L-SIL and H-SIL findings is in age group between 0-29 years old. Statistical analysis has shown a positive trend in number of younger patients with L-SIL and H-SIL (PAPA III and IV), with average age of patients in 2011 being 31.12±9.12 years old.
Introduction:Cervical carcinoma is one of the leading health issues for women throughout the world. In 90% of the cases cervical carcinoma develops after development of invasive lesions of the uterine cervix or 10-15 years before they are diagnosed using cytological screening–Papanicolau test. Infection with human papilloma virus is considered to be the basic etiological cause of development of CIN and cervical carcinoma.Goal:Of this research was to determine frequency and type of abnormal cytological results in HPV positive and HPV negative patients.Material and Methods:Research is descriptive analytical, comparative and partly epidemiological, of mostly clinically applicable character. Used data included information on total number of examinations, type of exam, results of cytological and pathohistological diagnostics, HPV findings in cervix smear and HPV type in the period between January 1, 2009 and December 31, 2011.Results:During the period of analysis total number of Pap tests was 6376 (43.33%), in comparison to other exams 7828 (56.67%). For this period total number of L-SIL and H-SIL (PAPA III) was 395 (6.20%), in comparison to other results 5894 (92.44%). After analysis largest subset of HPV positive patients had pathohistological diagnosis of CIN I that is 250 (43.10%) of them, then CIN II with 162 (27.93%) patients, CIN III with 149 (25.69) and 3 (0.52%) patients had CIS while 16 (2.76%) had a clear test result. We can conclude there is a statistically significant margin of frequency between positive HPV results in relation to diagnosis. Highest percentage of L-SIL and H-SIL (PAPA III) test results was in 2010 and was 9.5%, and lowest in 2009 with 4.34%. Largest number of patients, 43.0%, with HPV positive results after cervical smear had pathohistological diagnosis of CIN I.
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