We describe, herein, the synthesis, full characterization, and optical properties of four different ligands L1-L4 which associate an azo group, an imidazole unit, and a Schiff base fragment. The UV-visible absorption bands are characteristic of π→π⁎ and n→π⁎ transitions with an additional charge transfer between the azobenzene moiety and the imino group. Finally the determination of MIC80 values against pathogenic fungi such as S. apiospermum, A. fumigatus, and C. albicans revealed that these ligands have effective antifungal properties with highest activities (MIC80) on C. albicans for the azole based ligands L1-L3. DPPH radical scavenging of the studied ligands was also tested.
Newly synthesized mononuclear copper(II) and zinc(II) complexes containing an azo Schiff base ligand (L), prepared by condensation of 2‐hydroxy‐5‐(o‐tolyldiazenyl)benzaldehyde and propylamine, were obtained and then characterized using infrared and NMR spectroscopies, mass spectrometry and X‐ray diffraction. Ligand L behaves as a bidentate chelate by coordinating through deprotonated phenolic oxygen and azomethine nitrogen. The copper and zinc complexes crystallize in triclinic and orthorhombic systems, respectively, with space groups P−1 and Pca21. In these complexes, the Cu(II) ion is in a square planar geometry while the Zn(II) ion is in a distorted tetrahedral environment. The photochemical behaviors of ligand L, [Cu(L)2] and [Zn(L)2] were investigated. The azo group in L underwent reversible trans–cis isomerization under UV and visible irradiation. This process was inhibited for the complexes. In addition, ligand L and its copper and zinc complexes were assessed for their in vitro antibacterial activities against four pathogenic strains.
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