This multicentric, randomized, double-blind trial compared the efficacy and safety of netilmicin, 4.5 mg/kg od and 1.5 mg/kg tid, in patients with intra-abdominal infections. Of 114 patients enrolled, 57 patients (mean age 40.3 years) in the od group and 55 (mean age 36.8 years) in the tid group were evaluated for efficacy; 58 and 56 patients in corresponding groups were evaluated for safety. Among those evaluated for efficacy were 12 od-treated and 11 tid-treated patients with documented septicaemia, and 32 and 30 patients of respective groups with polymicrobial infections. Initially, 86 and 81 netilmicin-susceptible causative microorganisms were isolated in corresponding groups. Of these pathogens, 55% in the od group and 62% in the tid group were Escherichia coli. Daily dosage of netilmicin ranged from 3.70 to 4.71 mg/kg (mean 4.50) for the od group and from 3.06 to 4.76 mg/kg (mean 4.46) for the tid group. Duration of netilmicin therapy ranged from six to 13 days (mean 8.7 days) for od-treated patients and from seven to 16 days (mean 8.8 days) for tid-treated patients. Concomitant metronidazole was administered to 41 patients of the od group and 34 of the tid group; one patient in the tid group received clindamycin. Clinical and bacteriological responses were assessed, and peak and trough serum netilmicin levels were measured periodically, during therapy. Laboratory tests, including determinations of serum creatinine and blood urea nitrogen values, were performed throughout the trial. A clinical cure was achieved in 57/57 od-treated patients and 54/55 tid-treated patients; treatment failed in one tid-treated patient (1/55). In od and tid groups, 86/86 and 80/81 netilmicin-susceptible pathogens initially isolated were considered to be eliminated, respectively; one isolate (Esch. coli) persisted in the tid group. Mean peak serum netilmicin concentration in the od group was approximately two-fold greater than that in the tid group; mean trough serum netilmicin concentrations were similar for the two groups. Adverse reactions were limited to mild pain at the site of netilmicin administration in several patients in each treatment group. Netilmicin od and tid (alone or in combination with metronidazole) were similarly efficacious in the treatment of patients with appendicitis and other intra-abdominal infections caused by netilmicin-susceptible pathogens. Both dosage regimens of netilmicin were safe and well tolerated.

Biomechanical abnormalities of pronated feet accompanied by functional leg length disparity may increase the risk of skeletal muscle injury. Objective of the study is to prove that correction of pronated feet by the foot orthoses will reduce the creatine kinase-MM (CK-MM) concentrations as the muscle injury indicator. The design study was double blind randomized clinical trials with control. Research subjects were divided into two groups, group 1 used the foot orthoses while group 2 did not used the foot orthoses. The whole subject examined the concentrations of the CK-MM enzyme before, and 24–72 hours after the walking test. The walking test was conducted 15 minutes with maximum speed. The concentration of the CK-MM enzyme before walking test on treatment group was 70.07±15.33 International Unit (IU), similar with the control group was 69.85±17.03 IU (P=0.971). The increased in CK-MM enzyme concentrations 45 hours after the walking test was lower in the treatment group (7.8±9 IU) than the control group (22.0±11.5 IU) (P=0.001). The CK-MM enzyme concentrations continued to decline in the treatment group after the second walking test (77.21±17.47 IU), and after the third walking test (69.86±11.88 IU) (P=0.018). The foot orthoses for correcting the pronated feet on the young women with biomechanical abnormalities is able to reduce the degree of the skeletal muscle injury after walking activity.

No abstract

Introduction The medical profession has currently come to a con-clusion that the major problem in the future is failure of treatmentdue to antibiotic-resistant microorganisms.Objective The aim of this study was to determine the profile ofantibiotics used in the Pediatric Wards of Department of Child Health,Medical School, University of Indonesia, Cipto Mangunkusumo Hos-pital, Jakarta.Methods A descriptive retrospective study was conducted on all pa-tients hospitalized in the Pediatric Wards of Department of Child Health,Medical School, University of Indonesia, Cipto Mangunkusumo Hos-pital during June–July 2001. Data were obtained from the medicalrecords of the patients.Results Three hundreds and fifty-six hospitalized patients fulfilledthe inclusion criteria. The antibiotics were given to 48.7% of thepatients. The greatest user of antibiotics was the age group of 1-5year-old, 50% of patients had been given single antibiotic and therest given combined antibiotics. The ICU used antibiotics most fre-quently in contrast to the one-day care unit which used least. Thegreatest use of single antibiotic was in the class 1-2 wards whilecombined antibiotics were mostly used in the third class wards.Single antibiotics used were cefotaxime (49.4%), amoxicillin(20.7%), and ampicillin (11.55%). Combined antibiotics used wereampicillin + chloramphenicol (34.5%), cotrimoxazole (21.8%),cefotaxime + amikacin (5.7%), cefotaxime + cotrimoxazole (5.7%),and cefotaxime + isoniazid + rifampicin + pyrazinamide (5.7%).Conclusions The antibiotics most commonly used singly wascefotaxime. The combination of antibiotic mostly used was ampi-cillin + chloramphenicol

Pendahuluan: Terjadinya wabah virus corona atau yang disebut covid-19 di akhir tahun 2019, memberikan dampak yang cukup signifikan terhadap masalah kesehatan di seluruh dunia. Penyebaran yang cepat, belum adanya obat yang pasti dan angka kematian yang tinggi, menimbulkan stress terutama dalam bentuk kecemasan. Proses untuk menuju kesembuhan membutuhkan kemampuan individu dalam mempertahankan kondisi fisik dan psikologis yang baik. Salah satu koping konstruktif yang dapat dilakukan pasien dalam memperoleh kesembuhan dari penyakitnya adalah dengan mengembangkan efikasi diri (self efficacy). Metode: Metode penelitian yang digunakan adalah penelitian observasional dengan rancangan deskriptif analitik. Jumlah sampel yaitu 82 responden yang diambil berdasarkan consecutive sampling. Penelitian ini melibatkan responden yang sudah dinyatakan sembuh dari covid-19. Pengukuran Self Efficacy dengan menggunakan GSE (General Self Efficacy). Hasil: Self efficacy yang dimilki survivor covid-19 pada level yang tinggi yaitu 53.7% dari seluruh responden. Simpulan: Self efficacy yang cukup baik pada responden, mampu meminimalisir respon negative akibat stress menjadi respon positip sehingga menyebabkan mereka mampu sembuh dari covid-19.

Patients /Family patients satisfaction is an indicator to assess the quality of a hospital. During the Covid-19 pandemic, several problems emerged related to the quality of information provision and services provided. The purpose of this study was to describe the family satisfaction of Covid-19 patients with the provision of information and services provided. This research is a quantitative observational descriptive study with a variable of family satisfaction of covid-19 patients with the information and services provided. The population in this study is the families (husband / wife) of patients who recovered and were treated in the Covid-19 Isolation Ward RSUP dr. Kariadi Semarang with totaling 40 people. Sampling was done by using purposive sampling technique and the resulting sample was 30 respondents. Measurement of variables using a questionnaire providing information and service delivery. The results showed that the average patient's family expressed satisfaction with the provision of information (> 30) and services provided (>42). Innovation is needed to further improve service quality so that service quality will be even better.

During the Covid-19 patients’ treatment process in the hospital, nurses play an important role in preventing the Covid-19 outbreak through proper care and prevention procedures because nurses are in direct contact with Covid-19 patients. This study aimed to produce an analysis of nurses’ level of knowledge and attitudes regarding Covid-19 in the Covid-19 isolation ward of Dr Kariadi Hospital Semarang. This is a descriptive correlation study with a cross-sectional design. The study was conducted on 81 nurses who had or are currently taking care of Covid-19 patients in the isolation ward of Dr Kariadi Hospital Semarang by consecutive sampling. The data were analyzed by the Spearman Rho test. The results of the study showed that 81 nurses (100%) had a high level of knowledge regarding Covid-19 and had good attitudes towards Covid-19 prevention. The result showed a strong relationship between the level of knowledge and attitudes regarding Covid-19 with a positive correlation (r = 0.617). The study result concluded that the higher the level of knowledge, the better the attitude of nurses regarding Covid-19

Lansia merupakan kelompok umur manusia yang telah memasuki tahapan akhir fase kehidupannya. Permasalahan pada lansia adalah lansia tidak dapat mencapai integritas diri sehingga mengalami despair yang muncul sebagai perasaan sedih, merasa tidak disayangi oleh keluarganya, merasa kehilangan, serta merasa kehidupannya selama ini tidak berarti. Untuk mengatasi masalah integritas diri lansia dapat dilakukan dengan terapi life review. Penelitian ini bertujuan untuk menganalisa pengaruh terapi life review terhadap integritas diri lansia. Desain penelitian Pra-eksperimen (One-grup pra-post test design). Tempat penelitian di Griya Usia Lanjut di Kota Surabaya. Populasi penelitian ini adalah lansia yang berjumlah 21 orang lansia yang dipilih dengan teknik simple random sampling. Analisa data menggunakan uji Wilcoxon Signed Rank Test. Hasil menunjukkan ada pengaruh terapi life review terhadap integritas diri lansia (p value < 0,05). Terapi life review memberikan kesempatan kepada lansia untuk mengulang kembali pengalaman peristiwa masa lalu serta peneliti memberikan reinforcement positif sehingga lansia dapat menyampaikan emosi positfnya dan memberi arti akan peristiwa yang terjadi di masa lalu sehingga pada akhirnya lansia mencapai integritas diri. Pihak Griya Lanjut dapat mengadopt/mengambil contoh terapi life review dan menfasilitasi terapi life review bagi setiap lansia untuk mencegah terjadinya despair pada lansia yang tinggal di Griya Usia Lanjut.