Human welfare depends on the health of nature. Decades of ill-conceived management practices caused a decline in the quality of human life, as well as in biological and cultural diversity. Simultaneously, they increased social and ecological risks. For instance, mismanagement of urban rivers jeopardizes their ecological health and ability to provide ecosystem services. While demands for responsible urban riverscape design that fulfill both human and ecosystem needs are increasing, explicit recommendations to achieve these ambitious goals are still lacking. We present a first attempt of a conceptualization of Human–River Encounter Sites for urban rivers that targets reconciliation between humans and nature within urban river corridors. It builds upon the River Culture Concept with literature reviews and experiences from river restoration projects. We identify six tenets that are important to develop guidelines for Human–River Encounter Sites: health, safety, functionality, accessibility, collaboration, and awareness. This paper presents how these tenets can collectively help to harmonize the needs of citizens and biota, and to mitigate the current urban river crisis. This contribution feeds the debate on sustainable socio-ecological management of urban rivers and provides guidelines for the implementation of future urban river restorations and management efforts.
Opiates addiction is characterized by its long-term persistence. In order to study the enduring changes in long-term memory in hippocampus, a pivotal region for this process, we used suppression subtractive hybridization to compare hippocampal gene expression in morphine and saline-treated rats. Animals were subjected to an extended place preference paradigm consisting of four conditioning phases. Sensitization to the reinforcing effects of the drug occurred after three conditioning phases. After 25 days of treatment rats were euthanized and the complementary DNA (cDNA) from the hippocampus of morphine-dependent and saline-treated animals were then screened for differentially expressed cDNAs. The selected 177 clones were then subjected to a microarray procedure and 20 clones were found differentially regulated. The pattern of regulated genes suggests impairments in neurotransmitter release and the activation of neuroprotective pathways.
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