ObjectivesThe objective of this study was to assess whether the laterality of congenital diaphragmatic hernia (CDH) was a prognostic factor for neonatal survival.MethodsThis was a cohort study using the French national database of the Reference Center for Diaphragmatic Hernias. The principal endpoint was survival after hospitalization in intensive care.We made a comparative study between right CDH and left CDH by univariate and multivariate analysis. Terminations and stillbirths were excluded from analyses of neonatal outcomes.ResultsA total of 506 CDH were included with 67 (13%) right CDH and 439 left CDH (87%). Rate of survival was 49% for right CDH and 74% for left CDH (P < .01). Multivariate analysis showed two factors significantly associated with mortality: thoracic herniation of liver (OR 2.27; IC 95% [1.07‐4.76]; P = .03) and lung‐to‐head‐ratio over under expected (OR 2.99; IC 95% [1.41‐6.36]; P < .01). Side of CDH was not significantly associated with mortality (OR 1.87; IC 95% [0.61‐5.51], P = .26).ConclusionRate of right CDH mortality is more important than left CDH. Nevertheless after adjusting for lung‐to‐head‐ratio and thoracic herniation of liver, right CDH does not have a higher risk of mortality than left CDH.
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