Objectives: The objective of this study is to help identify the hematological profile of patients with diabetes Settings: The study was conducted at El-Beida Hospital, El-Beida City, Libya. Subjects and Methods: The study subjects selected for this study consist of 103 Libyan type 2 diabetic patients (79 males + 24 females) and 39 healthy non-diabetic subjects (29 males and 10 females) acted as controls. They were matched for age (56.1 ± 7.8 years vs. 55.0 ± 6.3 years. The hematocrit value (HCT), hemoglobin content, red blood cells count (RBCs) and mean corpuscular volume (MCV) concentration with increased white blood cells counts (WBCs), mean erythrocyte hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), lymphocytes and neutrophils levels were performed. Results: Hematological studies in the diabetic patients showed significantly lower HCT values, hemoglobin content, RBCs count and MCV concentration than in the controls. Greater total WBC counts, MCHC concentrations, MCH, lymphocytes and neutrophils counts were observed in the patients than in the controls. No differences were found between platelets counts in the diabetic patients and the control. Conclusions: Significant aberrations in some hematological parameters associated with carbohydrate, protein and lipid metabolisms was identified in this selected group of people with diabetes.