Aim:
To analyze the efficacy of eugenol on longevity by assessing its antioxidant effect using Caenorhabditis elegans as an animal model.
Background:
Eugenol is a major polyphenolic component of Ocimum sanctum (Tulsi) which attributes wide pharmacological activities and can serve as a biomarker. However, the possible effect of eugenol on longevity in Caenorhabditis elegans has not been reported.
Objective:
The objective of this investigation was to provide first scientific based results about effect of eugenol on longevity, slowing down of paralysis in Alzheimer’s model and mechanism behind it in Caenorhabditis elegans animal model system.
Results:
Extract of Ocimum sanctumand eugenol increased lifespan and provided indemnity against pro-oxidants. It also significantly improved healthy ageing and slowed the progression of neurodegeneration in CL4176 Alzheimer’s model of worm by increasing survival against prooxidants and slowing down the paralysis. Longevity effect was independent of the DAF-16 as observed by using DAF-16::GFP and daf-16 null mutant strains. These results implicate eugenol as a potent therapeutic compound which may curtail ageing and age related disorders like- Alzheimer’s disease.
Conclusion:
The present work demonstrated eugenol as a potential anti-ageing compound which may curtail ageing, improve heath span by enhancing resistance to oxidative stress and exerts its effect independent of DAF-16 pathway. So, it can be assumed that eugenol can be beneficial to humans as well, albeit further research is necessary before declaring it for human consumption.
Salicylic acid and amino acid are plant growth promoters. Therefore, the study entitled "Effect of salicylic acid and amino acid on late season peas growth and production" was conducted. The study has two factors: amino acid (Glycine) and salicylic acid each having four levels that were sprayed on peas. Analysis of data showed that maximum germination percentage (92.50 %), plant height (63.16 cm), primary branches plant -1 (2.80), leaves plant -1 (264.27), leaf chlorophyll content (57.25 SPAD), pods plant -1 (49.25), seeds pod -1 (10.41), pod length (11.74 cm) and yield ha -1 (1922.5 kg) having least days to flowering and pod formation (50.13 and 5.12 days) were noted in 225 mg L -1 amino acid. Salicylic acid levels showed that maximum germination percentage (95.83 %) height of plants (71.85 cm), leaves plant -1 (257.13), primary branches plant -1 (3.25), leaf chlorophyll content (55.81 SPAD),
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