Date (Phoenix dactylifera) seed and syringic acid exhibits antioxidative effect and lifespan extending properties in Caenorhabditis elegans

Jabeen, Amber; Parween, Nikhat; Sayrav, Kumar; Prasad, Birendra

doi:10.1016/j.arabjc.2020.10.028

Cited by 11 publications

(4 citation statements)

References 24 publications

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“…They reported that date seed extract extended the mean and maximum lifespans of C. elegans. Studies with date seeds also suggested that syringic acid, an antioxidant found in high amounts in date seed extracts, is related to prolonging nematode lifespans (Jabeen, A et al, 2020). In our study, dates were shown to have a similar amount of phenolic compounds, an indication of antioxidant content, compared to prunes.…”

Section: Resultssupporting

confidence: 64%

Dried Fruits, Especially Dates, Increase the Lifespan of Caenorhabditis Elegans

Kakugawa,

Katoh,

Murakawa

et al. 2023

Agriculture & Food

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The effects of five commercially available dried fruits on the longevity of nematodes were investigated. All five dried fruits significantly increased the lifespans relative to the control. In particular, dates extended the lifespan significantly more than the control and the other four dried fruits. The mean lifespan and maximum lifespan of the nematodes that consumed dates were 40.9 and 21% longer than those of the control group, respectively. The total concentration of polyphenol compounds was measured to investigate whether the lifespan-extending effect of dates was due to antioxidants. The results showed that the polyphenol contents of dates and prunes were higher than those of the other dried fruits. However, there was no significant difference in the total polyphenol concentrations between dates and prunes. Therefore, dates may contain substances other than polyphenol-related compounds that are responsible for their lifespan-extending effects, or which may promote the activities of polyphenols.

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Section: Resultssupporting

confidence: 64%

Dried Fruits, Especially Dates, Increase the Lifespan of Caenorhabditis Elegans

Kakugawa,

Katoh,

Murakawa

et al. 2023

Agriculture & Food

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“…Some contained phenolic acids including cinnamic acid, coumaric acid, sinapic acid, and their derivatives [ 44 ]. Date palm seeds at the Tamr stage of Medjool cultivar also contained gallic acid, p -coumaric acid, caffeic acid, and syringic acid [ 45 ], while p -coumaric acid, ferulic acid, sinapic acid, and cinnamic acid derivatives were detected in date palm seeds in Akerbouche, Deglet-Nour, Ougherouss, Tantbouchte, Tafiziouine and Tazerzait cultivars [ 46 ]. Date palm seeds in Mabseeli cultivar were also reported to contain gallic acid, protocatechuic acid, p -hydroxybenzoic acid, vanillic acid, caffeic acid, p -coumaric acid, m -coumaric acid, o -coumaric acid, and ferulic acid [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

A Comparison of the Nutritional and Biochemical Quality of Date Palm Fruits Obtained Using Different Planting Techniques

et al. 2021

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Date palm fruit (Phoenix dactylifera L.) is commonly consumed around the world and has recently become an economical crop in Eastern Thailand, especially the Barhi cultivar that can be consumed as fresh fruit. To maintain genetic qualities, date palm is populated through cell culture. This leads to high production costs, while access to this technique is limited. Increasing date palm population by simple seed planting is currently of interest as an alternative for local farmers. Nevertheless, information on nutritive values, bioactive compounds, and health-promoting bioactivities of seed originating from date palm fruit is unavailable. Effects of different planting origins (cell culture origin (CO) and seed origin (SO)) of date palm fruits at the Khalal stage of Barhi cultivar were investigated for nutritive values, bioactive compounds, and in vitro health-promoting properties via key enzyme inhibitions against obesity (lipase), diabetes (α-amylase, α-glucosidase, and dipeptidyl peptidase-IV), Alzheimer’s disease (cholinesterases and β-secretase), and hypertension (angiotensin-converting enzyme). Waste seeds as a by-product from date palm production were also examined regarding these properties to increase seed marketing opportunities for future food applications and other health-related products. CO and SO exhibited insignificant differences in energy, fat, and carbohydrate contents. SO had higher protein, dietary fiber, vitamin A, vitamin E, and calcium contents than CO, while CO contained higher contents of fructose, glucose and maltose. Higher phenolic contents in SO led to greater enzyme inhibitory activities than CO. Interestingly, seeds of date palm fruits mostly contained higher nutritive values than the flesh. No carotenoids were detected in seeds but higher phenolic contents resulted in greater enzyme inhibitory activities than recorded for fruit flesh. Results suggest that appropriate planting of date palm can support the development of novel date palm fruit products, leading to expansion of economic opportunities and investment in date palm fruit agriculture.

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“…Caenorhabditis elegans ( C. elegans ), a soil nematode, serves as a model organism for pharmacological studies, aging, and longevity ( Jabeen et al, 2020 ). It has a short life cycle, a short lifespan and produces a large number of offspring.…”

Section: Introductionmentioning

confidence: 99%

Leaf extract of Garcinia atroviridis promotes anti-heat stress and antioxidant effects in Caenorhabditis elegans

Chuaijit,

Punsawad,

Winoto

et al. 2024

Front. Pharmacol.

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Introduction:Garcinia atroviridis has been used for traditional medicines, healthy foods and tea. The chemical compositions and biological activities of fruit, stem bark and root have been widely studied. However, the phytochemical components and the biological activities in Garcinia atroviridis leaves (GAL) are limited. This research aims to study the phytochemical components and the stress resistance effects of GAL in Caenorhabditis elegans (C. elegans).Methods: To investigate the chemical components and antioxidant activities of GAL extract, the ethanol extract was characterized by liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF MS) analysis and C. elegans was used to evaluate the effects of GAL extracts on longevity and stress resistance.Results and discussion: The results revealed that the ethanol extract of GAL possesses free radical scavenging activities. Furthermore, GAL extract increased the lifespan of C. elegans by 6.02%, 15.26%, and 12.75% at concentrations of 25, 50, and 100 μg/mL, respectively. GAL extract exhibited improved stress resistance under conditions of heat and hydrogen peroxide-induced stress. The survival rates of GAL extract-treated worms were significantly higher than those of untreated worms, and GAL extract reduced reactive oxygen species (ROS) accumulation. Additionally, GAL extract treatment upregulated the expression of stress resistance-associated genes, including gst-4, sod-3, skn-1, and hsp16.2. GAL extract supplementation alleviated stress and enhanced longevity by inducing stress-related genes in C. elegans. The observed effects of GAL extracts may be attributed to the stimulation of oxidant enzymes mediated through DAF-16/FOXO and SKN-1/NRF2, as well as the enhancement of thermal defense in C. elegans. Collectively, this study provides the first evidence of the antioxidant activities of GAL and elucidates the underlying mechanisms of stress resistance.

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Date (Phoenix dactylifera) seed and syringic acid exhibits antioxidative effect and lifespan extending properties in Caenorhabditis elegans

Cited by 11 publications

References 24 publications

Dried Fruits, Especially Dates, Increase the Lifespan of Caenorhabditis Elegans

Dried Fruits, Especially Dates, Increase the Lifespan of Caenorhabditis Elegans

A Comparison of the Nutritional and Biochemical Quality of Date Palm Fruits Obtained Using Different Planting Techniques

Leaf extract of Garcinia atroviridis promotes anti-heat stress and antioxidant effects in Caenorhabditis elegans

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